Selenophene-Modified Boron Dipyrromethene-Based Photosensitizers Exhibit Photodynamic Inhibition on a Broad Range of Bacteria

Date

2022-09-27

Author

ÖZKETEN, AHMET ÇAĞLAR
Karaman, Osman
Ozdemir, Alara
Soysal, Isil
KIZILENİŞ, ÇAĞLAYAN
Chatzioglou, Aisegkioul Nteli
Çiçek, Yağız Arda
Kolemen, Safacan
Günbaş, Emrullah Görkem

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Microorganisms are crucial for human survival in view of both mutualistic and pathogen interactions. The control of the balance could be achieved by use of the antibiotics. There is a continuous arms race that exists between the pathogen and the antibiotics. The emergence of multidrug-resistant (MDR) bacteria threatens health even for insignificant injuries. However, the discovery of new antibiotics is not a fast process, and the healthcare system will suffer if the evolution of MDR lingers in its current frequency. The cationic photosensitizers (PSs) provide a unique approach to develop novel, light-inducible antimicrobial drugs. Here, we examine the antimicrobial activity of innovative selenophene-modified boron dipyrromethene (BODIPY)-based PSs on a variety of Gram (+) and Gram (-) bacteria. The candidates demonstrate a level of confidence in both light-dependent and independent inhibition of bacterial growth. Among them, selenophene conjugated PS candidates (BOD-Se and BOD-Se-I) are promising agents to induce photodynamic inhibition (PDI) on all experimented bacteria: E. coli, S. aureus, B. cereus, and P. aeruginosa. Further characterizations revealed that photocleavage ability on DNA molecules could be potentially advantageous over extracellular DNA possessing biofilm-forming bacteria such as B. cereus and P. aeruginosa. Microscopy analysis with fluorescent BOD-H confirmed the colocalization on GFP expressing E. coli.

URI

https://hdl.handle.net/11511/100080

Journal

ACS OMEGA

DOI

https://doi.org/10.1021/acsomega.2c02868

Collections

Department of Chemistry, Article

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Citation Formats

A. Ç. ÖZKETEN et al., “Selenophene-Modified Boron Dipyrromethene-Based Photosensitizers Exhibit Photodynamic Inhibition on a Broad Range of Bacteria,” ACS OMEGA, vol. 7, pp. 33916–33925, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/100080.