Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Versatile RNA: overlooked gems of the transcriptome.
Date
2023-01-31
Author
Erdem, Murat
Cicek, Mustafa
Erson Bensan, Ayşe Elif
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
70
views
0
downloads
Cite This
The critical role of RNA, its use and targetability concerning different aspects of human health are gaining more attention because our understanding of the versatility of RNA has dramatically evolved over the last decades. We now appreciate that RNA is far more critical than a messenger molecule and possesses many complicated functions. As a multifunctional molecule with its sequence, flexible structures and enzymatic abilities, RNA is genuinely powerful. Mammalian transcriptomes consist of a dynamically regulated plethora of coding and noncoding RNA types. However, some aspects of RNA metabolism remain to be explored. In this Viewpoint, we focus on the transcriptome's unconventional and possibly overlooked aspects to emphasize the importance of RNA in mammalian systems.
URI
https://hdl.handle.net/11511/102148
Journal
The FEBS journal
DOI
https://doi.org/10.1111/febs.16742
Collections
Department of Biology, Article
Suggestions
OpenMETU
Core
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system
Erson Bensan, Ayşe Elif (2008-10-01)
Since the discovery of microRNAs (miRNAs) in Caenorhabditis elegans, mounting evidence illustrates the important regulatory roles for miRNAs in various developmental, differentiation, cell proliferation, and apoptosis pathways of diverse organisms. We are just beginning to elucidate novel aspects of RNA mediated gene regulation and to understand how heavily various molecular pathways rely on miRNAs for their normal function. miRNAs are small non-protein-coding transcripts that regulate gene expression post-...
Functional characterization of microrna-125b expression in MCF7 breast cancer cell line
Tuna, Serkan; Erson Bensan, Ayşe Elif; Department of Biology (2010)
microRNA dependent gene expression regulation has roles in diverse processes such as differentiation, proliferation and apoptosis. Therefore, deregulated miRNA expression has functional importance for various diseases, including cancer. miR-125b is among the commonly downregulated miRNAs in breast cancer cells . Therefore we aimed to characterize the effects of miR-125b expression in MCF7 breast cancer cell line (BCCL) to better understand its roles in tumorigenesis. Here, we investigated mir-125 family mem...
RNA-biology ruling cancer progression? Focus on 3 ' UTRs and splicing
Erson Bensan, Ayşe Elif (Springer Science and Business Media LLC, 2020-09-01)
The protein-coding regions of mRNAs have the information to make proteins and hence have been at the center of attention for understanding altered protein functions in disease states, including cancer. Indeed, the discovery of genomic alterations and driver mutations that change protein levels and/or activity has been pivotal in our understanding of cancer biology. However, to better understand complex molecular mechanisms that are deregulated in cancers, we also need to look at non-coding parts of mRNAs, i...
Alternative Polyadenylation: Another Foe in Cancer
Erson Bensan, Ayşe Elif; Can, Tolga (2016-06-01)
Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer puzzle are still missing. In an effort to have a more comprehensive understanding of the development and progression of cancer, we have come to appreciate the value of the noncoding...
PageRank-flux On Graphlet-Guided-Network(PRO-GGNet): A Method for Pathway Reconstruction and Multi-Omic Data Integration
Arıcı, Kaan; Tunçbağ, Nurcan (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10)
The recent advancement of omic technologies provides snapshots of cells, tissues, or patients identifying prominent genes, proteins, metabolites, and small molecules. However, accumulated big data on various omic data types may inherently make diseases or perturbations incomprehensible. Network inference or reconstruction methods map a set of significantly altered proteins/genes/metabolites to a given reference network that is composed of already known relations or interactions. Followingly, the signals fro...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
M. Erdem, M. Cicek, and A. E. Erson Bensan, “Versatile RNA: overlooked gems of the transcriptome.,”
The FEBS journal
, 2023, Accessed: 00, 2023. [Online]. Available: https://hdl.handle.net/11511/102148.