A non-parametric circular network construction via simulations and a hidden Markov model for the HIV-1 protease cleavage site detection

Doğan Dar, Elif
In this thesis, problems regarding network structures are investigated. In the first part, a circular network model is built. In the literature, methods used to detect network structures of circular variables either have strong distributional assumptions or strict structural assumptions. To address these issues, a novel circular regression-based, non-parametric circular network model is proposed. The performance of the proposed method is examined in an extensive simulation study. In the second part, a method to utilize known network structures for further analyses is exemplified. An HMM model is built for the detection of the HIV-1 protease cleavage sites. By using feature selection and fuzzy clustering methods, a clever starting point is given to the Baum- Welch EM algorithm and the performance of earlier proposed methods is increased.


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Citation Formats
E. Doğan Dar, “A non-parametric circular network construction via simulations and a hidden Markov model for the HIV-1 protease cleavage site detection,” Ph.D. - Doctoral Program, Middle East Technical University, 2023.