Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Date

2023-05-01

Author

Fusar-Poli, Laura
Prachason, Thanavadee
Erzin, Gamze
Pries, Lotta-Katrin
Brondino, Natascia
Politi, Pierluigi
Delespaul, Philippe
Kenis, Gunter
Luykx, Jurjen J
Lin, Bochao D
Richards, Alexander L
Akdede, Berna
Binbay, Tolga
Altınyazar, Vesile
Yalınçetin, Berna
Gümüş-Akay, Güvem
Cihan, Burçin
Soygür, Haldun
Ulaş, Halis
Cankurtaran, Eylem Şahin
Kaymak, Semra Ulusoy
Mihaljevic, Marina M
Andric-Petrovic, Sanja
Mirjanic, Tijana
Bernardo, Miguel
Mezquida, Gisela
Amoretti, Silvia
Bobes, Julio
Saiz, Pilar A
García-Portilla, Maria Paz
Sanjuan, Julio
Escarti, Maria Jose
Santos, José Luis
Jiménez-López, Estela
Arrojo, Manuel
Carracedo, Angel
López, Gonzalo
González-Peñas, Javier
Parellada, Mara
Maric, Nadja P
Atbaşoğlu, Cem
Üçok, Alp
Alptekin, Köksal
Saka, Meram Can
Arango, Celso
O'Donovan, Michael
van Os, Jim
Rutten, Bart PF
Guloksuz, Sinan

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Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) - a cumulative environmental exposure score - was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group. Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI -0.76 to -0.03) and healthy controls (B=-0.63, 95% CI -1.06 to -0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings. Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.

Subject Keywords

Cannabis use, Childhood trauma, Emotion recognition, Environment, Psychosis

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85151411106&origin=inward
https://hdl.handle.net/11511/102914

Collections

Department of Psychology, Article