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Nazar İleri Ercan
E-mail
nileri@metu.edu.tr
Department
Department of Chemical Engineering
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Phytochemicals in Pancreatic Cancer Treatment: A Machine Learning Study
Genc, Destina Ekingen; Ozbek, Ozlem; Oral, Burcu; Yıldırım, Ramazan; İleri Ercan, Nazar (2024-01-09)
The discovery of new strategies and novel therapeutic agents is crucial to improving the current treatment methods and increasing the efficacy of cancer therapy. Phytochemicals, naturally occurring bioactive constituents d...
Coarse-grained modeling of polystyrene-modified CNTs and their interactions with lipid bilayers
Gul, Gulsah; Faller, Roland; İleri Ercan, Nazar (2023-05-01)
In the present work, we describe Martini3 coarse-grained models of polystyrene and carboxyl-terminated polysty-rene functionalized carbon nanotubes (CNTs) and investigate their interactions with lipid bilayers with and wit...
Polystyrene-modified carbon nanotubes: Promising carriers in targeted drug delivery
Gul, Gulsah; Faller, Roland; İleri Ercan, Nazar (2022-11-15)
To design drug-delivery agents for therapeutic and diagnostic applications, understanding the mechanisms by which covalently functionalized carbon nanotubes penetrate and interact with cell membranes is of great importance...
The Toxicity of Polystyrene-Based Nanoparticles in Saccharomyces cerevisiae Is Associated with Nanoparticle Charge and Uptake Mechanism
Ozbek, Ozlem; O. Ulgen, Kutlu; İleri Ercan, Nazar (2021-04-19)
Polystyrene latex (PSL) nanoparticles (NPs), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes, and hybrid NPs that have different concentrations, sizes, surface charges, and functional groups were used to determin...
Cytotoxicity analysis of nanoparticles by association rule mining
Gul, Gulsah; Yildirim, Ramazan; İleri Ercan, Nazar (2021-04-01)
Understanding the toxicity behavior of NPs is of great importance to ensure efficient delivery to intracellular targets without causing cytotoxicity, to measure the long-term effects of nanoparticles (NPs), and to predict ...
Fullerene translocation through peroxidized lipid membranes
Gul, Gulsah; İleri Ercan, Nazar (2021-02-15)
Recent cytotoxicity research suggests that fullerenes can enter the cell and cross the blood-brain barrier. However, the underlying toxicity mechanism behind the penetration of fullerenes through biological membranes is st...
Pore length- and ion concentration-dependent ionic current in cylindrical nanopores: an atomistic molecular dynamics study
İleri Ercan, Nazar (2019-10-01)
The sensing of individual molecules as they pass through nanopores under an external field is a popular research field. The approach is simply based on the detectable temporary blockades in the ionic current as the molecul...
Understanding Interactions of Curcumin with Lipid Bilayers: A Coarse-Grained Molecular Dynamics Study
İleri Ercan, Nazar (2019-01-01)
The interactions of curcumin with various lipid bilayers (POPC, DOPC, oxidized POPC, and oxidized DOPC) and model biomembranes (symmetric bacteria and yeast plasma membranes, as well as asymmetric mammalian plasma membrane...
Molecular Dynamics Modeling of Methylene Blue-DOPC Lipid Bilayer Interactions
İleri Ercan, Nazar; Stroeve, Pieter; Tringe, Joseph W.; Faller, Roland (2018-04-10)
We present a coarse-grained MARTINI model for methylene blue (MB) and investigate the interactions of MB with dioleylphosphatidylcholine (DOPC) lipid bilayers by molecular dynamics simulations. Our results show that the ch...
Improved controlled release of protein from expanded-pore mesoporous silica nanoparticles modified with co-functionalized poly(n-isopropylacrylamide) and poly(ethylene glycol) (PNIPAM-PEG)
Yu, Erick; Lo, Allison; Jiang, Linda; Petkus, Bradley; İleri Ercan, Nazar; Stroeve, Pieter (2017-01-01)
Novel pore-expanded mesoporous silica nanoparticles (MSNs) with pore sizes of approximately 11 nm were synthesized and modified with thermoresponsive, poly(n-isopropylacrylamide) (PNIPAM) gating groups on the nanoparticle ...
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