Large eddy simulations of hemodynamics in aortic stenosis models

Date

2023-6-15

Author

Savaşkan, Sinan

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Aortic stenosis is a heart condition that refers to the incomplete opening of the aortic valve, resulting in decreased flow area and transition to turbulence in the post-stenotic flow field. This turbulent activity induces pressure fluctuations on the vessel walls that generate distinct sound waves, called murmurs. These sound waves are used in determining the severity of the stenosis in auscultation-based diagnosis methods. In this study, large eddy simulations (LES) are employed to investigate these murmurs emitted from the vessel walls and correlate them with the severity of the stenosis. Additionally, post-stenotic flow fields under steady and pulsating conditions using Newtonian and non-Newtonian blood models are investigated in detail and the suitability of large eddy simulations in computational fluid dynamics (CFD) analyses of aortic stenoses is verified by comparing the obtained results with a reference solution. The simulations utilize simplified aorta models with the rigid wall assumption and a mean inlet Reynolds number of 2000. The results indicate that LES is a suitable tool for hemodynamic analyses that can accurately capture the source location of murmurs and break frequencies of the sounds emitted from the stenosed vessels. Additionally, the level of turbulence, the intensity of the murmurs, and break frequency are found to be positively correlated with stenosis severity.

Subject Keywords

Computational fluid dynamics, Large eddy simulations, Aortic stenosis, Hemodynamics, Turbulence induced acoustics

URI

https://hdl.handle.net/11511/104463

Collections

Graduate School of Natural and Applied Sciences, Thesis