Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system

Date

2023-10-01

Author

Karaduman, Aysenur
Karoglu-Eravsar, Elif Tugce
Kaya, Utku
Aydın, Alaz
Adams, Michelle M.
Kafaligonul, Hulusi

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (achesb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system.

Subject Keywords

Acetylcholinesterase, Aging, Motion detection, Second-order motion, Zebrafish

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85164327460&origin=inward
https://hdl.handle.net/11511/104727

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Graduate School of Informatics, Article