Studies towards Zinc(II) bisdipicolylamine complex bearing molecules, liposomes and glass microspheres for the inactivation and sequestration of bacterial cells

Date

2023-7-07

Author

Selvi, Hatice Tuğba

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The widespread and frequent unnecessary use of antibiotics has resulted in the frequent and continuous emergence of bacterial strains resistant to antibiotics in clinical use. As a result, antibiotics are becoming obsolete, and now pathogenic bacterial strains exist that do not respond to known antibiotics. Antibiotic-resistant bacteria are one of the most important risks to public health. There are several approaches that could be taken to tackle this problem. One approach is to enhance the selectivity of antibiotic agents by conjugating them with bacterial targeting groups to widen their therapeutic window. Zinc(II) bisdipicolylamine (Zn2(BDPA)) complexes, which are known to bind to bacterial membranes and walls, can be used for this purpose. Another approach is antibacterial photodynamic therapy (PDT). In PDT a photosensitizer (e.g., porphyrins) is used to absorb light and generate singlet oxygen (1O2) which is highly toxic towards bacterial cells, although this toxicity is not cell-specific. The probability of emergence of widespread bacterial resistance towards 1O2 is known to be low. Yet another potential approach is to remove bacterial from liquids, particularly blood, and thus reduce the infective potential. The aims of the studies summarized in this thesis are three-fold: The first objective is to evaluate the PDT efficacy of a number of Zn2(BDPA) complex bearing porphyrin derivatives against a number bacterial strains. The second objective is to develop Zn2(BDPA) complex bearing liposomes and to explore their antibiotic potential. The third is to develop Zn2(BDPA) complex bearing glass microspheres for sequestration of bacterial cells from liquids, blood in particular.

Subject Keywords

Porphyrin, Photodynamic therapy, Glass microspheres, Liposomes, Bisdipicolylamine ligand

URI

https://hdl.handle.net/11511/104794

Collections

Graduate School of Natural and Applied Sciences, Thesis