Enantioselective synthesis of 4-hydroxy-3-(3-oxo-l-phenyl butyl)-2H-1-benzopyran-2-one (Warfarin)

Date

1996-12-01

Author

Demir, Ayhan Gürbüz
Tanyeli, Cihangir
Gülbeyaz, Volkan
Akgün, Hülya

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Oral anticoagulant Warfarin (4-hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1-benzopyran-2-one) is synthesized in optically active form starting from 4-hydroxycoumarin via formation of optically active enamines followed by Michael addition reaction with benzyliden acetone at low temperature. Different amines gave 17-68% ee and the chemical yield was 22-71%, depending on the reaction conditions and the structure of chiral amines.

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030515441&origin=inward
https://hdl.handle.net/11511/106675

Journal

Turkish Journal of Chemistry

Collections

Department of Educational Sciences, Article

Citation Formats

A. G. Demir, C. Tanyeli, V. Gülbeyaz, and H. Akgün, “Enantioselective synthesis of 4-hydroxy-3-(3-oxo-l-phenyl butyl)-2H-1-benzopyran-2-one (Warfarin),” Turkish Journal of Chemistry, vol. 20, no. 2, pp. 139–145, 1996, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030515441&origin=inward.