Arachidonic acid modulation of [3H]naloxone specific binding to rat brain opioid receptors

Date

1998-12-01

Author

Öktem, Hüseyin Avni
Apaydin, S.

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Arachidonic acid effect on binding of [3H]naloxone to rat brain membranes, were studied at opioid receptor subtype level. Arachidonic acid inhibited opioid receptor binding in a dose-dependent manner, both in the presence and absence of sodium. With blockage experiments it was shown that delta-opioid receptors were modulated by arachidonic acid to a greater extent than that of mu-opioid receptors. On the other hand, there was no significant difference in terms of IC50 values for arachidonic acid inhibiton of [3H]naloxone binding at agonist and antagonist configuration of the receptor subtypes.

Subject Keywords

[3H]naloxone, Arachidonic acid, Mu- and delta-opioid receptors, Rat brain opioid receptors

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032469501&origin=inward
https://hdl.handle.net/11511/107937

Collections

Department of Biology, Article