Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development

1990-01-01
Szucs, M.
Öktem, Hüseyin Avni
Szuts, V.
Lengyel, I.
Toth, G.
Coscia, C.J.
Wollemann, M.
Brains of mature and neonatal (P-3) rats were subjected to subcellular fractionation. Light membranes of P-3 contained more [3H]DAGO binding sites (40% of total μ sites vs 16% in adult) with greater sensitivity to GTP. Affinity labelling with [3H]DAGOCK revealed that the major subunit has a molecular weight of about 50 kDa in the synaptic as well as light membrane fractions.
The International Narcotics Research Conference
Citation Formats
M. Szucs et al., “Molecular structure, regulation and subcellular distribution of mu opioid receptors during postnatal development,” presented at the The International Narcotics Research Conference, 1990, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025084123&origin=inward.