Affinity labeling of opioid receptors with enkephalin analogues

Date

1990-01-01

Author

Borsodi, A.
Öktem, Hüseyin Avni
Benyhe, S.
Varga, E.
Moitra, J.
Takacs, J.

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Chloromethyl ketone derivatives of enkephalins and Tyr-D-Ala-Gly(Me)Phe-Gly-ol (DAGO) were synthesized in normal and in tritiated form and were shown to react irreversibly at opioid receptors. Affinity of the chloromethyl ketone derivatives toward the μ site is greater than that of the parent compounds. It was shown in several studies (including autoradiography) with these ligands that the μ receptor protein contains only one type of binding subunit whose apparent M(r) is 58000.

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025086313&origin=inward
https://hdl.handle.net/11511/108018

Conference Name

The International Narcotics Research Conference

Collections

Department of Biology, Conference / Seminar

Citation Formats

A. Borsodi, H. A. Öktem, S. Benyhe, E. Varga, J. Moitra, and J. Takacs, “Affinity labeling of opioid receptors with enkephalin analogues,” presented at the The International Narcotics Research Conference, 1990, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025086313&origin=inward.