A CMOS-based highly scalable flexible neural electrode interface

Date

2023-06-07

Author

Zhao, Eric T.
Hull, Jacob M.
Hemed, Nofar Mintz
Uluşan, Hasan
Bartram, Julian
Zhang, Anqi
Wang, Pingyu
Pham, Albert
Ronchi, Silvia
Huguenard, John R.
Hierlemann, Andreas
Melosh, Nicholas A.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Perception, thoughts, and actions are encoded by the coordinated activity of large neuronal populations spread over large areas. However, existing electrophysiological devices are limited by their scalability in capturing this cortex-wide activity. Here, we developed an electrode connector based on an ultra-conformable thin-film electrode array that self-assembles onto silicon microelectrode arrays enabling multithousand channel counts at a millimeter scale. The interconnects are formed using microfabricated electrode pads suspended by thin support arms, termed Flex2Chip. Capillary-assisted assembly drives the pads to deform toward the chip surface, and van der Waals forces maintain this deformation, establishing Ohmic contact. Flex2Chip arrays successfully measured extracellular action potentials ex vivo and resolved micrometer scale seizure propagation trajectories in epileptic mice. We find that seizure dynamics in absence epilepsy in the Scn8a+/- model do not have constant propagation trajectories.

URI

https://hdl.handle.net/11511/111087

Collections

Department of Electrical and Electronics Engineering, Article