Innovative Fluorescent Polymers in Niosomal Carriers: A Novel Approach to Enhancing Cancer Therapy and Imaging

Date

2024-01-01

Author

Tornaci, Selay
ERGİNER HASKÖYLÜ, MERVE
BULUT, UMUT
Sener, Beste
Persilioglu, Elifsu
KALAYCILAR, İSMAİL BERGUTAY
Celik, Emine Guler
YARDİBİ, HASRET
Siyah, Pinar
Karakurt, Oğuzhan
Çırpan, Ali
Gokalsin, Baris
Senisik, Ahmet Murat
Barlas, Firat Baris

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Cancer is anticipated to become the pioneer reason of disease-related deaths worldwide in the next two decades, underscoring the urgent need for personalized and adaptive treatment strategies. These strategies are crucial due to the high variability in drug efficacy and the tendency of cancer cells to develop resistance. This study investigates the potential of theranostic nanotechnology using three innovative fluorescent polymers (FP-1, FP-2, and FP-3) encapsulated in niosomal carriers, combining therapy (chemotherapy and radiotherapy) with fluorescence imaging. These cargoes are assessed for their cytotoxic effects across three cancer cell lines (A549, MCF-7, and HOb), with further analysis to determine their capacity to augment the effects of radiotherapy using a Linear Accelerator (LINAC) at specific doses. Fluorescence microscopy is utilized to verify their uptake and localization in cancerous versus healthy cell lines. The results confirmed that these niosomal cargoes not only improved the antiproliferative effects of radiotherapy but also demonstrate the practical application of fluorescent polymers in in vitro imaging. This dual function underscores the importance of dose optimization to maximize therapeutic benefits while minimizing adverse effects, thereby enhancing the overall efficacy of cancer treatments.

Subject Keywords

fluorescent polymers, niosomes, radiotherapy, theranostic treatment

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85202844100&origin=inward
https://hdl.handle.net/11511/111247

Collections

Department of Chemistry, Article