Water-Soluble Silicon Quantum Dots toward Fluorescence-Guided Photothermal Nanotherapy

Date

2022-05-03

Author

Özbilgin, İrem Nur Gamze
Yamazaki, Tomohiko
Watanabe, Junpei
Hong-Tao Sun, Hong-Tao Sun
Hanagata, Nobutaka
Shirahata, Naoto

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We report carboxy-terminated silicon quantum dots(SiQDs) that exhibit high solubility in water due to the high molecularcoverage of surface monolayers, bright light emission with highphotoluminescence quantum yields (PLQYs), long-term stability inthe PL property for monitoring cells, less toxicity to the cells, and a highphotothermal response. We prepared water-soluble SiQDs by thethermal hydrosilylation of 10-undecenoic acid on their hydrogen-terminated surfaces, provided by the thermal disproportionation oftriethoxysilane hydrolyzed at pH 3 and subsequent hydrofluoric etching.The 10-undecanoic acid-functionalized SiQDs (UA:SiQDs) showedlong-term stability in hydrophilic solvents including ethanol and water(pH 7). We assess their interaction with live cells by means of cellularuptake, short-term toxicity, and, for thefirst time, long-term cytotoxicity.Results show that UA:SiQDs are potential candidates for theranostics,with their good optical properties enabling imaging for more than 18 days and a photothermal response having a 25.1%photothermal conversion efficiency together with the direct evidence of cell death by laser irradiation. UA:SiQDs have lowcytotoxicity with full viability of up to 400 mu g/mL for the short term and a 50% cell viability value after 14 days of incubation at a 50 mu g/mL concentration

URI

https://hdl.handle.net/11511/111931

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Department of Metallurgical and Materials Engineering, Article