Crosstalk Between Phase-Separated Membraneless Condensates and Membrane-Bound Organelles in Cellular Function and Disease

Date

2025-01-01

Author

Torun, Aydan
Tuğral, Hoşnaz
Banerjee, Sreeparna

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Compartmentalization in eukaryotic cells allows the spatiotemporal regulation of biochemical processes, in addition to allowing specific sets of proteins to interact in a regulated as well as stochastic manner. Although membrane-bound organelles are thought to be the key players of cellular compartmentalization, membraneless biomolecular condensates such as stress granules, P bodies, and many others have recently emerged as key players that are also thought to bring order to a highly chaotic environment. Here, we have evaluated the latest studies on biomolecular condensates, specifically focusing on how they interact with membrane-bound organelles and modulate each other's functions. We also highlight the importance of this interaction in neurodegenerative and cardiovascular diseases as well as in cancer.

Subject Keywords

Cancer, Cardiovascular diseases, Condensate, Liquid-liquid phase separation, Membraneless granules, Neurodegenerative diseases, Organelle

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105010351157&origin=inward
https://hdl.handle.net/11511/115250

Collections

Department of Biology, Article