The impact of changes in breast density over time on breast cancer risk

Date

2025-12-01

Author

Kulturoglu, Mahmut Onur
Aydin, Ferit
Sagdic, Mehmet Furkan
Aslan, Fatih
Oflaz, Zarina
Danisman, Furkan Berk
Kalaylıoğlu Akyıldız, Zeynep Işıl
Dogan, Lutfi

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

15893
views

81
downloads

Cite This

Mammographic density is not static; instead, it is influenced by a range of factors, including age, number of births, hormone use, and menopause. The current study aims to evaluate the association between both baseline breast density and its changes over time and the risk of breast cancer in both premenopausal and postmenopausal women. Patients over the age of 40 who presented between 2022 and 2024 for either breast cancer diagnosis or routine breast cancer screening were retrospectively reviewed. The patterns of changes in density in the mammograms were analyzed, comparing those who developed cancer with those who did not. In premenopausal patients, a statistically significant relationship was found between cancer development and both age (p = 0.01, OR = 0.90 [0.82–0.98]) and the rate of change in density in the mammograms (p = 0.04, OR = 7.46 [1.09–50.40]). In postmenopausal patients, A statistically significant relationship could not be demonstrated (p = 0.60, OR = 1.72 [0.24–12.30]). The rate of decrease in fibroglandular tissue density was found to be associated with breast cancer in premenopausal patients. Applying this finding and monitoring the pattern and rate of density changes in mammographic images may allow more personalized risk-reduction strategies.

Subject Keywords

Breast cancer, Breast density, Density rate of change

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105010066753&origin=inward
https://hdl.handle.net/11511/115295

Collections

Department of Statistics, Article