Hydroxyapatite and polycaprolactone composites as potential biomaterials in biomedical applications

Date

2025-06-14

Author

Copur, Oyku
Tezcaner, Ayşen
Evis, Zafer

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Hydroxyapatite and polycaprolactone (HA/PCL) composites show significant potential in biomedical applications, especially in bone tissue engineering. HA's high hardness and brittleness, the low stiffness and flexible mechanical structure of PCL, and the microstructural properties such as porosity and crystallinity can be controlled in composite fabrication and designed to suit the desired biomedical applications. Integrating ion doping into the HA structure or surface modifications to PCL involves designing biocompatible supporting composites. This modification can enhance cellular reactions such as increased cell proliferation, migration, and differentiation, as mentioned in in vitro studies. To provide a comprehensive understanding of the benefits of the produced composites, chemical synthesis of HA and PCL, mechanical, structural, and biological properties are examined, and the application areas are specified. This review shows the promising role of HA/PCL composites in advancing biomedical applications and developing effective treatment methods. The aim is to provide a comprehensive overview of the role of HA/PCL composites in biomedical fields such as hard and soft tissue and drug delivery, as well as the path ahead for increasing clinical studies. This study compiles the current potential research from HA and PCL synthesis to HA/PCL fabrication and laboratory and clinical studies.

URI

https://hdl.handle.net/11511/115303

Collections

Department of Engineering Sciences, Article