Studies on biosynthesis of bacilysin by bacillus subtilis

Özcengiz, Gülay


Development of new methods for the synthesis of pyrazoles, 4-iodopyrazoles, isoxazoles and 1,2,4-oxadiazoles
Kıvrak, Arif; Zora, Metin; Department of Chemistry (2011)
Synthesis of five-membered heteroaromatic compounds such as pyrazoles, isoxazoles and 1,2,4-oxadiazoles are important for pharmaceutical industry and material science due to their applications. Although there are many methods to prepare such compounds, new variants continue to appear since they exhibit a wide range of biological and medicinal activities. In this thesis, new methods were developed for the synthesis of 4-iodopyrazoles, pyrazoles, isoxazoles, 1,2,4-oxadiazoles and/or 1,2,4-oxadiazepines. In th...
Comparative analysis of product and by-product distributions in defined and complex media in serine alkaline protease production by recombinant Basillus subtilis
Oktar, Ceren; Çalık, Pınar; Department of Chemical Engineering (2003)
In this study, firstly the effects of aspartic acid group amino acids -which were reported to be the potential bottleneck in serine alkaline protease (SAP) synthesis- on SAP production were investigated by substituting at a concentration range of 0-15 mM by using recombinant Bacillus subtilis carrying pHV1434::subC gene. All aspartic acid group amino acids except threonine inhibited SAP activity when CAA= 2.5 mM. The highest SAP activities with asparagine, aspartic acid, lysine, threonine, isoleucine and me...
Studies towards synthesis of urea containing helical polymers
Çalışgan, Gizem; Akdağ, Akın; Doğan, Özdemir; Department of Chemistry (2016)
This thesis deals with design and synthesis of chiral polyurea type polymers. These polymers were analyzed with molecular mechanics that they could take a helical form. The polymers are polyurea type polymers and ureas are synthesized by treating isocyanates with amines. Starting from tartaric acid, ((4S,5S)-2,2-dimethyl-1,3- dioxolane-4,5diyl)dimethaneamine was synthesized. The other diamine was naturally occuring L-lysine. These diamine functionalized compounds were treated with pphenylene diisocyanate sy...
Improvement of Pectinase Production by Co-culture of Bacillus spp. Using Apple Pomace as a Carbon Source
Kuvvet, Ceren; UZUNER, SİBEL; Çekmecelioğlu, Deniz (2019-05-01)
Increasing interest in using food and agricultural wastes for low cost enzyme production continues in fermentation industry. Bacteria, especially Bacillus subtilis, are known to produce pectinases in synthetic media and media amended with agricultural wastes as a carbon source, whereas the potential of co-culturing Bacillus species to produce pectinases has not been fully studied yet. In this study, co-culture of B. subtilis and B. pumilus was optimized for solid load and pH to maximize pectinase production...
Study of high mass Higgs using pp -> qqH
Yildiz, HD; Zeyrek, Mehmet Tevfik (2003-08-01)
The observability of the Higgs signal in the mass range of 200-800 GeV is investigated in the weak boson fusion channel at the CMS experiment at LHC. The weak boson fusion channel is characterized by two final state jets at large pseudorapidity. The forward calorimeter plays a key role in detecting these jets. The significant signals are obtained for H --> WW --> lvjj, H --> ZZ --> lljj and H --> ZZ --> llvv. Importance of the forward jet tagging and the central jet veto is emphasized to extract the signal ...
Citation Formats
G. Özcengiz, “Studies on biosynthesis of bacilysin by bacillus subtilis,” Ph.D. - Doctoral Program, Middle East Technical University, 1989.