Interfacial synergy in a CoS2/Ketjen black hybrid electrode enabling electrochemical detection of sertraline hydrochloride

Date

2026-01-01

Author

OKAN AYDIN, MELTEM
Sanko, Vildan
Tekin, Hilal
Külah, Haluk

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A hybrid electrode integrating cobalt disulfide (CoS2) nanosheets with high-surface-area Ketjen black (KB) was developed for the electrochemical detection of sertraline hydrochloride (SER), a widely prescribed antidepressant increasingly found as an environmental contaminant. CoS2 nanosheets synthesized hydrothermally at 180 °C exhibited well-defined crystalline features and a nanosheet morphology confirmed via detailed characterizations. The incorporation of KB provided enhanced conductivity and active interfacial sites, yielding a synergistic hybrid surface with improved electron transfer kinetics. The optimized KB + CoS2-modified screen-printed carbon electrode demonstrated a sharp oxidation peak corresponding to the two-electron, two-proton transformation of SER, achieving a limit of detection (LOD) of 0.0037 nM with a wide linear range of 1 nM–1 µM. The sensor displayed remarkable reproducibility (RSD = 1.32%) and high recovery of 108–123% and 103–110.6% in surface water and wastewater samples, respectively. This study highlights the interfacial synergy of KB and CoS2 as a promising route toward an efficient, scalable, and sustainable electrochemical platform for pharmaceutical residue monitoring.

Subject Keywords

Cobalt disulfide, Electrochemical sensor, Environmental monitoring, Pharmaceutical contaminants, Sertraline

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105044819495&origin=inward
https://hdl.handle.net/11511/120488

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Department of Basic English, Article