Molecular approach with Fourier transform infrared spectroscopy to different pathological systems (diabetes mellitus and arteriovenous malformation) with various treatments

Chronic hypoperfusion alters the content and structure of proteins and lipids of rat brain homogenates: a Fourier transform infrared spectroscopy study Toyran, N; Zorlu, F; Donmez, G; Oge, K; Severcan, Feride (2004-10-01) Arteriovenous malformations (AVMs), masses of abnormal blood vessels which grow in the brain, produce high flow shunts that steal blood from surrounding brain tissue, which is chronically hypoperfused. Hypoperfusion is a condition of inadequate tissue perfusion and oxygenation, resulting in abnormal tissue metabolism. Fourier transform infrared (FTIR) spectroscopy is used in this study to investigate the effect of hypoperfusion on homogenized rat brain samples at the molecular level. The results suggest tha...
Structural alterations in rat liver proteins due to streptozotocin-induced diabetes and the recovery effect of selenium: Fourier transform infrared microspectroscopy and neural network study Bozkurt, Ozlem; Bayari, Sevgi Haman; Severcan, Mete; Krafft, Christoph; Popp, Juergen; Severcan, Feride (2012-07-01) The relation between protein structural alterations and tissue dysfunction is a major concern as protein fibrillation and/or aggregation due to structural alterations has been reported in many disease states. In the current study, Fourier transform infrared microspectroscopic imaging has been used to investigate diabetes-induced changes on protein secondary structure and macromolecular content in streptozotocin-induced diabetic rat liver. Protein secondary structural alterations were predicted using neural ...
Fourier Transform Infrared Spectroscopic Studies of Diabetic Rat Heart Crude Membranes Severcan, Feride; Kaptan, Nese; Turan, Belma (Hindawi Limited, 2003) Application of mid infrared spectroscopy in diabetic tissues will be presented which highlight the promise of this technique in medical research. Examples presented mainly will focus on diabetic rat heart crude membranes. Diabetes mellitus (DM) was induced in rats by streptozotocin (STZ) injection that is one of the most popular experimental models for the study of type I diabetes. The shift in the peak positions, bandwidths and the intensity of the bands in FTIR spectra were analyzed to have valuable struc...
Numerical study of combustion and emission characteristics of dual-fuel engines using 3D-CFD models coupled with chemical kinetics Maghbouli, Amin; Saray, Rahim Khoshbakhti; Shafee, Sina; Ghafouri, Jafar (2013-04-01) Dual-fuel combustion provides a relatively easy and inexpensive alternative to conventional diesel engine combustion by drastically reducing fuel consumption with comparable performance characteristics. Accurate simulation of the dual-fuel combustion requires utilization of a detailed chemistry combined with a flow simulation code. In the present study, the combustion process within the diesel and diesel/gas dual-fuel engine is investigated by use of a coupled 3D-CFD/chemical kinetics framework. In this stu...
Biophysical characterization of proteins in solution and human fluids for cancer diagnosis applications using fourier transform infrared spectroscopy Abbas, Sherif Abbas Mousa; Severcan, Feride; Severcan, Mete; Department of Biology (2016) Proteins play very important roles in cells regulation and structure. Understanding of proteins structures greatly help in understanding of the mechanism of action of these proteins. The optical spectroscopic techniques such as Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopy can be used to study proteins in its native environment without complicated sample preparations that is required for a high resolution technique such as x-ray. In order to calculate the protein secondary struc...

Citation Formats

N. Toyran Al-Otaibi, “Molecular approach with Fourier transform infrared spectroscopy to different pathological systems (diabetes mellitus and arteriovenous malformation) with various treatments,” Ph.D. - Doctoral Program, Middle East Technical University, 2003.