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Reinvestigation of the synthetic and mechanistic aspects of manganese(III) acetate mediated reactions : synthesis of 1,2,4-trisubstituted pyrroles via amination / annulation reactions of chloroenones with chiral amine compounds
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index.pdf
Date
2006
Author
İğdir, A. Çiğdem
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The first part of the thesis presents the reinvestigation of the synthetic and mechanistic aspects of manganese (III) acetate mediated reactions. The main concern about this subject was to perform a ¢- acetoxylation reactions of enones and saturated systems in shorter reactions times and higher yields than the ones known in literature reproducibly. Although successful a ¢-acetoxylation of a great variety of substrates have been reported so far, there are some problems associated with the use of Mn(OAc)3. Considering that there are not many simple methods for the direct acetoxylation of enones, optimization of Mn(OAc)3 mediated a ¢-acetoxylation of enones and reaching its maximum potential has a great importance from a synthetic and economical point of view. In the second part of the thesis, 1,2,4-trisubstituted pyrrole derivatives were the target molecules to be synthesized. Although there are quite a number of methods available for the synthesis of pyrroles, most of them involve multistep synthetic operations which lower the overall yield. There are limited reports on the preparation of the enantiomers of pyrrole derivatives having 1-N directly linked to the stereogenic center. Thus, developing a new synthetic method for the efficient preparation of polysubstituted pyrroles without racemization still remains an attractive goal.
Subject Keywords
Manganese compounds
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http://etd.lib.metu.edu.tr/upload/12607643/index.pdf
https://hdl.handle.net/11511/16515
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Graduate School of Natural and Applied Sciences, Thesis