Acceleration of phosphodiester hydrolysis by novel metal complexes

Yukruk, Funda


Modulation of Estrogen Response Element-Driven Gene Expressions and Cellular Proliferation with Polar Directions by Designer Transcription Regulators
Muyan, Mesut; Yasar, Pelin; Ayaz, Gamze; User, Sirma Damla; Kazan, Hasan Huseyin; Huang, Yanfang (2015-08-21)
Estrogen receptor a (ER alpha), as a ligand-dependent transcription factor, mediates 17 beta-estradiol (E2) effects. ERa is a modular protein containing a DNA binding domain (DBD) and transcription activation domains (AD) located at the amino-and carboxyl-termini. The interaction of the E2-activated ERa dimer with estrogen response elements (EREs) of genes constitutes the initial step in the ERE-dependent signaling pathway necessary for alterations of cellular features. We previously constructed monomeric t...
Activation of survival pathways in nutrient restricted colorectal cancer cells
Oral, Göksu; Banerjee, Sreeparna; Department of Biology (2023-1-9)
Limited nutrient availability in the tumor microenvironment can cause metabolic rewiring of cancer cells, resulting in the activation of various stress response pathways such as autophagy for survival. Our study showed for the first time that incubation of LoVo cells with a nutrient restriction medium containing low glucose, glutamine, and serum for 48 h resulted in the concurrent activation of two antagonistic proteins: the AMP Kinase pathway (AMPK) which is phosphorylated in response to low energy and act...
Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines
Kars, Meltem Demirel; Iseri, Ozlem Darcansoy; Gündüz, Ufuk; Molnar, Jozsef (2008-01-01)
Background: Ineffectiveness of anticancer drugs is frequently observed in cancer chemotherapy. The resistance of tumor cells to various cytotoxic drugs is defined as multidrug resistance (MDR). The purpose of this study is to investigate the potential reversal effect of some synthetic and natural chemicals on drug-resistant MCF-7 cell lines. The effects of potential MDR modulators combined with some anticancer drugs were also studied. Methods: Flow cytometry, MTT cytotoxicity assays and checkerboard combina...
Özcengiz, Gülay; DEMAIN, AL (Springer Science and Business Media LLC, 1990-10-01)
Modulation of Ruthenium II MLCT Emission by Metal Ions
Baytekin, Hasan Tarık (2000-08-20)
Citation Formats
F. Yukruk, “Acceleration of phosphodiester hydrolysis by novel metal complexes,” Middle East Technical University, 1999.