Dopaminergic modulation of attentional gating between sensory modalities in drosophila melanogaster

Download

index.pdf

Date

2016

Author

Serhan, Barış

Metadata

Show full item record

Item Usage Stats

164
views

60
downloads

The fruit fly -Drosophila melanogaster- is one of the most popular model organisms for translational neuroscience and medicine. The monoamines like dopamine, norepinephrine and serotonin that modulate cognitive processes have homologs in the fly brain. The availability of genetic tools that enable selective manipulation of aminergic neurons in the fly brain provide an enormous advantage to study the neural circuits underlying cognitive processes. In our experiments, the role of dopaminergic modulation in the allocation of attention between two sensory modalities -vision and taste- was addressed by using a cross-modal attention protocol. First, the effects of food deprivation and stimulus parameters on the probability of responding to a looming stimulus versus feeding were assayed. Then, the flies that were mutants for different types of dopaminergic or octopaminergic receptors/transporters were tested to understand the involvement of amine modulators in attentional allocation. Finally, a particular mutation on a dopamine (i.e. Dop1R1) receptor gene was examined in order to pinpoint the state-dependent responsiveness and the cross-modal suppression in the Drosophila model, which might underlie preliminary characteristics of attention in any attention-like mechanism.

Subject Keywords

Attention., Dopamine., Senses and sensation., Drosophila melanogaster.

URI

http://etd.lib.metu.edu.tr/upload/12620508/index.pdf
https://hdl.handle.net/11511/26058

Collections

Graduate School of Informatics, Thesis

Suggestions

OpenMETU
Core

Influence of STRO-1 selection on osteogenic potential of human tooth germ derived mesenchymal stem cells Ercal, Pinar; Pekozer, Gorke G.; Gumru, Osman Z.; KÖSE, GAMZE; Ramazanoglu, Mustafa (Elsevier BV, 2017-10-01) Mesenchymal stem cells derived from the human tooth germ (hTGSCs) are a heterogeneous cell population that can differentiate into osteogenic, neurogenic, and adipogenic lineages. The aim of this study was to compare the osteogenic differentiation capacity of STRO-1 positive (STRO-1 +) hTGSCs and unsorted heterogeneous hTGSCs and to establish if STRO-1 + cells are more committed to osteogenic differentiation. HTGSCs were isolated from impacted third molar tooth germ tissues of adolescents, and a subpopulatio...
Antioxidant and cytotoxic properties of Salvia Absconditiflora and effects on CYP1A1, CYP1B1 gene expressions in breast cancer cell lines Yılmaz, Selis; İşcan, Mesude; Güray, Tülin; Department of Biochemistry (2013) Salvia genus is a widely cultivated genus and used in medicine for various purposes as having antimicrobial, antioxidant, anticarcinogen and anti-inflammatory features. In this study the aim was to investigate phenolic composition of Salvia absconditiflora and understand the possible effects of those constituents in cancer related drug metabolizing enzymes. Salvia absconditiflora showed 80,43 % Radical Scavenging Activity against DPPH radical. Total flavonoid content was found as one third of total phenolic...
iDrosophila1: An orthology-based reconstruction of genome-scale metabolic network model for Drosophila melanogaster Cesur, Müberra Fatma; Patil, Kiran Raosaheb; Çakır, Tunahan (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Drosophila melanogaster is a promising workhorse that includes conserved counterparts of essential human systems. In addition, this organism has a high conservation in terms of disease-associated genes. Thus, it has been widely used to elucidate the molecular mechanisms underlying complex human diseases. Despite experimental advances, metabolic modeling of Drosophila is still limited. This prompted us to reconstruct a comprehensive and highly curated metabolic network model for this organism using an orthol...
MODULATION OF CYTOCHROME P450s AND ANTIOXIDANT ENZYMES BY CAFFEIC ACID, p-COUMARIC ACID AND QUERCETIN-RICH ANATOLIAN PROPOLIS IN HUMAN ADENOCARCINOMA HT-29 CELLS ALTAY, AHMET; İrtem Kartal, Deniz; Sagdicoglu-Celep, Gulcin; Güray, Nülüfer Tülün; Bozoglu, Faruk (2018-01-01) Propolis, which is a complex resinous material has diverse pharmacological and biological properties. Phase I and II enzymes are responsible for detoxication and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in metabolic activation of xenobiotics. This study was designed to investigate the in vitro modulatory effects of Anatolian propolis and its phenolic contents; caffeic acid, quercetin and p-coumaric acid on t...
The effects of CGAS-STING-TBK1 pathway and NKT cell-activating ligand alpha-galactosylceramide on LEISHMANIA MAJOR infection and protection Dünüroğlu, Emre; Gürsel, Mayda; Department of Molecular Biology and Genetics (2022-2-8) Leishmaniasis is a multi-faceted group of diseases caused by various species of Leishmania protozoa. Depending on the infecting Leishmania species, the disease manifests as recurrent cutaneous, mucocutaneous or visceral leishmaniasis all of which can be devastating for infected individuals. Lack of a protective vaccine and the rise of drug resistances in Leishmania spp. prompted us to explore preventative vaccine candidates and novel drugs against Leishmania major. In the first part of this thesis, we evalu...

Citation Formats

B. Serhan, “Dopaminergic modulation of attentional gating between sensory modalities in drosophila melanogaster,” M.S. - Master of Science, Middle East Technical University, 2016.