Synthesis and biotransformation studies of various appealing synthons for biologically active natural products

Download
093347.pdf
2000
Sezen, Bengü
Show full item record
31
views
0
downloads
https://hdl.handle.net/11511/2639
Graduate School of Natural and Applied Sciences, Thesis

Suggestions

Synthesis, Anticancer Activity and Docking Studies of New Phenylaminopyrimidine Derivatives
Demirci, Aslı; Durmaz, İrem; Atalay, Rengül; Küçükgüzel, İlkay (null; 2017-06-25)
Synthesis and biological evaluation of optically active conjugated gamma- and delta-lactone derivatives
ŞARDAN, Melis; Sezer, Serdar; GUNEL, Aslihan; AKKAYA, MAHİNUR; Tanyeli, Cihangir (2012-09-15)
An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted gamma- and delta-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated.
Synthesis and surface modification studies of biomedical polyurethanes to improve long term biocompatibility
Aksoy, Eda Ayşe; Hasırcı, Nesrin; Department of Polymer Science and Technology (2008)
Thrombus formation and blood coagulation is a major problem associated with blood contacting products such as catheters, vascular grafts and artificial hearts. An intense research is being conducted towards the synthesis of new hemocompatible materials and mdifications of surfaces with biological molecules. In this study, polyurethane (PU) films were synthesized in medical purity from diisocyanate and polyol without using any other ingredients and the chemical, thermal and mechanical properties were charact...
Synthesis, Characterization and Evaluation of Cytotoxic Activities of Novel Aziridinyl Phosphonic Acid Derivatives
Khan, Rehan; Ulusan, Sinem; Banerjee, Sreeparna; Doğan, Özdemir (Wiley, 2019-11-01)
New aziridine 2-phosphonic acids were prepared by monohydrolysis of the aziridine 2-phosphonates that were obtained by the modified Gabriel-Cromwell reaction of vinyl phosphonate or alpha-tosylvinyl phosphonate with a primary amine or a chiral amine. The cellular cytotoxicity of these compounds was tested against the HCT-116 colorectal cancer cell lines and the CCD-18Co normal colon fibroblast lines using the MTT assay. Three of the synthesized phosphonic acid derivatives 2e (ethyl hydrogen {(2S)-1-[(1S)-1-...
Synthesis, spectroscopic and electrochemical studies of perylene containing conjugated copolymers
Bayseç, Şebnem; Toppare, Levent Kamil; Yılmaz, Levent; Department of Polymer Science and Technology (2013)
The synthesis , spectroscopic and electrochemical properties of a series of donor-acceptor (DA) type polymers by changing the donor unit (thiophene, dithienopyrrole) polymer backbone were investigated.The synthesized CoP1 and CoP2 were designed to investigate the effect of copolymerization and insertion of perylene tetracarboxylic dimide (PDI) on the structure of benzotriazole (BTz) based polymers. For CoP1 1,7-dibromo-perylene diimide,4,7-dibromo-2-dodecyl-2H-benzo[d][1,2,3]triazole and 2,5 bis(tributylsta...
Citation Formats
B. Sezen, “Synthesis and biotransformation studies of various appealing synthons for biologically active natural products,” Middle East Technical University, 2000.
METU IIS - Integrated Information Service open@metu.edu.tr