Enzymatic desymmetrization of meso-2,3-bis(acetoxymethyl) and bis(hydroxymethyl) substituted hexachloronorbornadiene derivatives

2004-1
Tanyeli, Cihangir
Karadağ, Timur
Akhmedov, İdris Mecitoğlu
meso-Bis(acetoxymethyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2,5-diene and i)ieso-bis(hydroxymethyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2,5-diene were transformed into chiral monoesters with 65-92% ee via enzymatic desymmetrization using various lipases. The absolute configuration was determined by transforming 2-acetoxymethyl-3-hydroxymethyl-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2,5-diene into the 2-acetoxymethyl-3-hydi-oxymethylbicyclo[2.2.1]hepta-2,5-diene of known absolute configuration.
Citation Formats
C. Tanyeli, T. Karadağ, and İ. M. Akhmedov, “Enzymatic desymmetrization of meso-2,3-bis(acetoxymethyl) and bis(hydroxymethyl) substituted hexachloronorbornadiene derivatives,” pp. 307–310, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/28150.