Pınar Çalık

E-mail

pcalik@metu.edu.tr

Department

Department of Chemical Engineering

ORCID

0000-0002-9628-6538

Scopus Author ID

6603737686

Web of Science Researcher ID

AAZ-8050-2020

Biochemical production from sustainable carbon sources by Komagataella phaffii Çalık, Pınar (2025-07-01) The use of sustainable carbon sources (SCSs) for biochemical production is needed to facilitate the chemical process industries transition towards the net-zero age and greener economy. The use of SCSs such as crude glycero...
Saccharomyces cerevisiae cis-acting DNA sequences curation pipeline (Sc-cADSs-CP): Master transcription factors prediction in yeasts Yaman, Oğuz Ulaş; Avcı, Beste; Çalık, Pınar (2022-12-15) © 2022 Elsevier B.V.Designing promoter architectures hinges on genomic and functional annotation. Saccharomyces cerevisiae is the first model yeast whose databases host genomic and functional annotation information. To pre...
Hybrid-architectured promoter design to engineer expression in yeast Gündüz Ergün, Burcu; Çalık, Pınar (Academic Press Inc., 2021-01-01) Engineered promoters are key components that allow engineered expression of genes in the cell-factory design. Promoters having exceptional strength are attractive candidates for designing metabolic engineering strategies f...
Hybrid-architectured promoter design to deregulate expression in yeast Ergun, Burcu Gunduz; Çalık, Pınar (2021-01-01) Hybrid-architectured promoter design to deregulate expression in yeast under modulating power of carbon sources involves replacing native cis-acting DNA sequence(s) with de novo synthetic tools in coordination with master ...
Hybrid-architectured promoter design to engineer expression in yeast Ergun, Burcu Gunduz; Çalık, Pınar (2021-01-01) Engineered promoters are key components that allow engineered expression of genes in the cell-factory design. Promoters having exceptional strength are attractive candidates for designing metabolic engineering strategies f...
Hybrid-architectured promoter design to deregulate expression in yeast Gündüz Ergün, Burcu; Çalık, Pınar (Academic Press Inc., 2021-01-01)
Ethanol-based bioindustries enable evolution of knowledge-based bioeconomies to sustainable models Çalık, Pınar (2020-12-24)
Ethanol fed-batch bioreactor operation to enhance therapeutic protein production in Pichia pastoris under hybrid-architectured ADH2 promoter Wehbe, Omar; Yaman, Oğuz Ulaş; Çalık, Pınar (Elsevier BV, 2020-12-15) We presented ethanol fed-batch bioreactor operations (FBBOs) designed for enhanced recombinant human growth hormone (rhGH) production in Pichia pastoris constructed with novel hybrid-architectured ADH2 promoter, PADH2-Cat8...
Hybrid-architectured double-promoter expression systems enhance and upregulate-deregulated gene expressions in Pichia pastoris in methanol-free media Demir, Irem; Çalık, Pınar (Springer Science and Business Media LLC, 2020-10-01) Double-promoter expression system (DPES) design as de novo metabolic engineering strategy enables fine-tuned and enhanced gene expression. We constructed a collection of monodirectional hybrid-architectured DPESs with engi...
Transcriptional regulatory proteins in central carbon metabolism ofPichia pastorisandSaccharomyces cerevisiae Kalender, Ozge; Çalık, Pınar (2020-09-01) System-wide interactions in living cells and discovery of the diverse roles of transcriptional regulatory proteins that are mediator proteins with catalytic domains and regulatory subunits and transcription factors in the ...

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