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Tolga Can
E-mail
tcan@metu.edu.tr
Department
Department of Computer Engineering
ORCID
0000-0002-5532-0154
Scopus Author ID
6602569668
Web of Science Researcher ID
D-1395-2010
Publications
Theses Advised
Open Courses
Projects
Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer
Assidicky, Ridho; Tokat, Unal Metin; Tarman, Ibrahim Oguzhan; Saatci, Ozge; Ersan, Pelin Gulizar; Raza, Umar; Ogul, Hasan; Riazalhosseini, Yasser; Can, Tolga; Sahin, Ozgur (2022-03-01)
Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer that is frequently treated with chemotherapy. However, many patients exhibit either de novo chemoresistance or ultimately develop...
A prelude to the proximity interaction mapping of CXXC5
Ayaz, Gamze; Turan, Gizem; Olgun, Çağla Ece; Kars, Gizem; Karakaya, Burcu; Yavuz, Kerim; Demiralay, Oyku Deniz; Can, Tolga; Muyan, Mesut; Yasar, Pelin (2021-09-01)
CXXC5 is a member of the zinc-finger CXXC family proteins that interact with unmodified CpG dinucleotides through a conserved ZF-CXXC domain. CXXC5 is involved in the modulation of gene expressions that lead to alterations...
A CpG island promoter drives the CXXC5 gene expression
Yasar, Pelin; Kars, Gizem; Yavuz, Kerim; Ayaz, Gamze; Oguztuzun, Cerag; Bilgen, Ecenaz; Suvaci, Zeynep; Cetinkol, Ozguel Persil; Can, Tolga; Muyan, Mesut (2021-08-01)
CXXC5 is a member of the zinc-finger CXXC family that binds to unmethylated CpG dinucleotides. CXXC5 modulates gene expressions resulting in diverse cellular events mediated by distinct signaling pathways. However, the mec...
MotifGenie: A Python Application for Searching Transcription Factor Binding Sequences Using ChIP-Seq Datasets
Oguztuzun, Cerag; Yasar, Pelin; Yavuz, Kerim; Muyan, Mesut; Can, Tolga (2021-05-17)
Motivation: Next generation sequencing enabled the fast accumulation of genomic data at public repositories. This technology also made it possible to better understand the regulation of gene expression by transcription fac...
JOA: Joint Overlap Analysis of multiple genomic interval sets
Otlu, Burcak; Can, Tolga (Springer Science and Business Media LLC, 2019-03-08)
BackgroundNext-generation sequencing (NGS) technologies have produced large volumes of genomic data. One common operation on heterogeneous genomic data is genomic interval intersection. Most of the existing tools impose re...
Transcription Elongation in Connection to 3’UTR Ends
Özgül, İbrahim; Can, Tolga; Erson Bensan, Ayşe Elif (null; 2018-09-08)
Transcription machinery is a coordinated and complex process, where various proteins have dynamic interactions. We are interested in better understanding how transcription related processes determine the end of 3’UTRs.3’UT...
Deregulated APA and cancer specific APA isoforms
Begik, Oguzhan; Ercan, Melda; Cingoz, Harun; Can, Tolga; ÖYKEN, MERVE; Erson Bensan, Ayşe Elif (2018-07-01)
Certain aspects of diagnosis, prognosis, and treatment of cancer patients are still important challenges to be addressed. We developed a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden complexit...
Alternative Polyadenylation Patterns for Novel Gene Discovery and Classification in Cancer
BEGIK, Oguzhan; ÖYKEN, MERVE; ALICAN, Tuna Cinkilli; Can, Tolga; Erson Bensan, Ayşe Elif (2017-07-01)
Certain aspects of diagnosis, prognosis, and treatment of cancer patients are still important challenges to be addressed. Therefore, we propose a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden ...
A multiplex primer design algorithm for target amplification of continuous genomic regions
OZTURK, Ahmet Rasit; Can, Tolga (2017-06-19)
Background: Targeted Next Generation Sequencing (NGS) assays are cost-efficient and reliable alternatives to Sanger sequencing. For sequencing of very large set of genes, the target enrichment approach is suitable. However...
Alternative Polyadenylation patterns for novel gene discovery and classification in cancer
Beğik, Oğuzhan; Öyken, Merve; Can, Tolga; Erson Bensan, Ayşe Elif (2017-06-03)
Certain aspects of diagnosis, prognosis and treatment of cancer patients are still important challenges to be addressed. Therefore, we propose a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden c...
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