Tolga Can

E-mail
tcan@metu.edu.tr
Department
Department of Computer Engineering
Scopus Author ID
Web of Science Researcher ID
A CpG island promoter drives the CXXC5 gene expression
Yasar, Pelin; Kars, Gizem; Yavuz, Kerim; Ayaz, Gamze; Oguztuzun, Cerag; Bilgen, Ecenaz; Suvaci, Zeynep; Cetinkol, Ozguel Persil; Can, Tolga; Muyan, Mesut (2021-08-01)
CXXC5 is a member of the zinc-finger CXXC family that binds to unmethylated CpG dinucleotides. CXXC5 modulates gene expressions resulting in diverse cellular events mediated by distinct signaling pathways. However, the mec...
JOA: Joint Overlap Analysis of multiple genomic interval sets
Otlu, Burcak; Can, Tolga (Springer Science and Business Media LLC, 2019-03-08)
BackgroundNext-generation sequencing (NGS) technologies have produced large volumes of genomic data. One common operation on heterogeneous genomic data is genomic interval intersection. Most of the existing tools impose re...
Transcription Elongation in Connection to 3’UTR Ends
Özgül, İbrahim; Can, Tolga; Erson Bensan, Ayşe Elif (null; 2018-09-08)
Transcription machinery is a coordinated and complex process, where various proteins have dynamic interactions. We are interested in better understanding how transcription related processes determine the end of 3’UTRs.3’UT...
Deregulated APA and cancer specific APA isoforms
Begik, Oguzhan; Ercan, Melda; Cingoz, Harun; Can, Tolga; ÖYKEN, MERVE; Erson Bensan, Ayşe Elif (2018-07-01)
Certain aspects of diagnosis, prognosis, and treatment of cancer patients are still important challenges to be addressed. We developed a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden complexit...
Alternative Polyadenylation Patterns for Novel Gene Discovery and Classification in Cancer
BEGIK, Oguzhan; ÖYKEN, MERVE; ALICAN, Tuna Cinkilli; Can, Tolga; Erson Bensan, Ayşe Elif (2017-07-01)
Certain aspects of diagnosis, prognosis, and treatment of cancer patients are still important challenges to be addressed. Therefore, we propose a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden ...
A multiplex primer design algorithm for target amplification of continuous genomic regions
OZTURK, Ahmet Rasit; Can, Tolga (2017-06-19)
Background: Targeted Next Generation Sequencing (NGS) assays are cost-efficient and reliable alternatives to Sanger sequencing. For sequencing of very large set of genes, the target enrichment approach is suitable. However...
Alternative Polyadenylation patterns for novel gene discovery and classification in cancer
Beğik, Oğuzhan; Öyken, Merve; Can, Tolga; Erson Bensan, Ayşe Elif (2017-06-03)
Certain aspects of diagnosis, prognosis and treatment of cancer patients are still important challenges to be addressed. Therefore, we propose a pipeline to uncover patterns of alternative polyadenylation (APA), a hidden c...
APA isoform diversity in triple negative breast cancers
AKMAN TUNCER, HESNA BEGÜM; ÖYKEN, MERVE; AĞUŞ, HIZLAN HINCAL; Erdem, Murat; Çiçek, Esra; Can, Tolga; Erson Bensan, Ayşe Elif (2017-04-05)
Alternative polyadenylation (APA) plays a role in gene expression regulation generally by shortening of 3'UTRs and relieving microRNA-mediated repression. Therefore, APA is gaining increased attention as a potential mechan...
Comparison of tissue/disease specific integrated networks using directed graphlet signatures
Sönmez, Arzu Burçak; Can, Tolga (2017-03-22)
Background: Analysis of integrated genome-scale networks is a challenging problem due to heterogeneity of high-throughput data. There are several topological measures, such as graphlet counts, for characterization of biolo...
Identification of a potential cancer related lncRNA
Beğik, Oğuzhan; Cinkilli, Tuna; Öyken, Merve; Can, Tolga; Erson Bensan, Ayşe Elif (null; 2016-11-15)
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