Gülay Özcengiz

E-mail

ozcengiz@metu.edu.tr

Department

Department of Biology

ORCID

0000-0002-8628-3202

Scopus Author ID

7003366111

Web of Science Researcher ID

ABA-1707-2020

Dynamic comparison of Histophilus somni Outer Membrane Vesicles (OMVs) Aktaş, Caner; Okay, Sezer; Özcan, Servet; Ayaz-Güner, Şerife; Özcengiz, Gülay (2023-10-13) Aim: Histophilus somni is a clinicaly important gram-negative pathogen that causes thromboembolic meningoencephalitis, pneumonia, polyarthritis and acute myocarditis in cattle, as well as infections of the urogenital tract...
Two formulations of coronavirus disease-19 recombinant subunit vaccine candidate made up of S1 fragment protein P1, S2 fragment protein P2, and nucleocapsid protein elicit strong immunogenicity in mice Özcengiz, Erkan; Keser, Duygu; Özcengiz, Gülay; Çelik, Gözde; ÖZKUL, AYKUT; İnçeh, Fatma Nur (2022-12-01) Coronavirus disease (COVID-19) is ongoing as a global epidemic and there is still a need to develop much safer and more effective new vaccines that can also be easily adapted to important variants of the pathogen. In the p...
An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus KURT KIZILDOĞAN, ASLIHAN; Celik, Gozde; unsaldi, Eser; ÖZCAN, SERVET; AYAZ GÜNER, ŞERİFE; Özcengiz, Gülay (2022-09-01) Clavulanic acid (CA) is a clinically important secondary metabolite used to treat infectious diseases. We aimed to decipher complex regulatory mechanisms acting in CA biosynthesis by analyzing transcriptome- and proteome-w...
Comparative biological network analysis for differentially expressed proteins as a function of bacilysin biosynthesis in Bacillus subtilis Kutnu, Meltem; İşlerel, Elif Tekin; Tunçbağ, Nurcan; Özcengiz, Gülay (2022-08-03) © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.The Gram-positive bacterium Bacillus subtilis produces a diverse range of seconda...
Proteomic Analysis of a hom-Disrupted, Cephamycin C Overproducing Streptomyces clavuligerus Unsaldi, Eser; KURT KIZILDOĞAN, ASLIHAN; ÖZCAN, SERVET; Becher, Dorte; Voigt, Birgit; Aktas, Caner; Özcengiz, Gülay (2021-01-01) Background: Streptomyces clavuligerus is prolific producer of cephamycin C, a medically important antibiotic. In our former study, cephamycin C titer was 2-fold improved by disrupting homoserine dehydrogenase (hom) gene of...
Dynamic proteomic analysis of Phanerochaete chrysosporium under copper stress Okay, Sezer; Yildirim, Volkan; Buttner, Knut; Becher, Dorte; Özcengiz, Gülay (Elsevier BV, 2020-07-15) The model white rot fungus Phanerochaete chrysosporium is frequently preferred for heavy metal accumulation studies due to its high resistance to heavy metals, including copper (Cu). Here, the response of P. chrysosporium ...
Regulation of biofilm formation bymarTinSalmonellaTyphimurium Eran, Zeynep; AKÇELİK, MUSTAFA; Yazici, Betul Cansu; Özcengiz, Gülay; AKÇELİK, NEFİSE (Springer Science and Business Media LLC, 2020-07-01) In this study, we aimed at identifying the regulatory role ofmarTgene, known as the regulator ofmisL, on 15 different biofilm-related genes inS.Typhimurium 14028 strain. We also tested the strains for their ability to form...
Analysis of a bac operon-silenced strain suggests pleiotropic effects of bacilysin in Bacillus subtilis Ertekin, Ozan; Taskin, Ash Aras; Demir, Mustafa; Karataş, Ayten; Özcengiz, Gülay (Springer Science and Business Media LLC, 2020-04-01) Bacilysin, as the simplest peptide antibiotic made up of only L-alanine and L-anticapsin, is produced and excreted by Bacillus subtilis under the control of quorum sensing. We analyzed bacilysin-nonproducing strain OGU1 wh...
Dynamic comparative secretome analysis of Bacillus subtilis standard strain and its bacilysin-deleted mutant. Özcengiz, Gülay (2019-11-11)
Biological network modeling based on differentially expressed proteins in a bacilysin-deficient strain of Bacillus subtilis Özcengiz, Gülay; Tunçbağ, Nurcan (2019-07-23)

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