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Pelin Mutlu

Central Laboratory
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Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery
Parsian, Maryam; Mutlu, Pelin; Yalcin, Serap; Gündüz, Ufuk (2020-01-01)
Background: Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic moie...
Co-delivery of Doxorubicin and D-alpha-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles
Metin, Esra; Mutlu, Pelin; Gündüz, Ufuk (2018-01-01)
Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, no...
Mutlu, Pelin; Azarkan, Serap Yalcin; Pourianazar, Negar Taghavi; Yucel, Meral; Gündüz, Ufuk (2018-01-01)
Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activit...
Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery
PARSIAN, MARYAM; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2016-12-30)
Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an adv...
Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug
PARSIAN, Maryam; UNSOY, Gozde; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2016-08-05)
Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility...
Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population
Mutlu, Pelin; Mutlu, Murad; Yalcin, Serap; Yaylaci, Atilay; Unsoy, Gozde; Saylam, Guleser; Akm, Istemihan; Gündüz, Ufuk; Korkmaz, Hakan (2015-12-01)
DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cance...
An update on molecular biology and drug resistance mechanisms of multiple myeloma
Mutlu, Pelin; Kiraz, Yağmur; Gündüz, Ufuk; Baran, Yusuf (Elsevier BV, 2015-12)
Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are sever...
Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met Polymorphisms in a Turkish Population and Their Association with the Risk of Chronic Lymphocytic Leukemia
Mutlu, Pelin; Elci, Mualla Pinar; Yildirim, Murat; Nevruz, Oral; Cetin, Ahmet Turker; Avcu, Ferit (2015-09-01)
DNA repair systems are essential for cellular functions. Defects due to sequence variations in DNA repair genes can lead severe failure of cell functions and causing many cancer types including leukemia. The aim of this st...
Detection of XRCC1 gene polymorphisms in Turkish head and neck squamous cell carcinoma patients: a comparative analysis with different populations
Mutlu, Pelin; Mutlu, Murad; Yalcin, Serap; Unsoy, Gozde; Yaylaci, Atilay; Saylam, Guleser; Akin, Istemihan; Korkmaz, Hakan; Gündüz, Ufuk (2015-03-01)
Purpose: X-ray repair cross-complementing (XRCC1) is one of the most important genes for the maintenance of genomic integrity and protection of cells from DNA damage. Although tobacco and alcohol consumption are the major ...
The-137G/C Polymorphism in Interleukin-18 Gene Promoter Contributes to Chronic Lymphocytic and Chronic Myelogenous Leukemia Risk in Turkish Patients
Yalcin, Serap; Mutlu, Pelin; Cetin, Turker; Sarper, Meral; Ozgur, Gokhan; Avcu, Ferit (2015-01-01)
Objective: Interleuldn-18 (IL-18) is a cytokine that belongs to the IL-1 superfamily and is secreted by various immune and nonimmune cells. Evidence has shown that 1L-18 has both anticancer and procancer effects. The aim o...