Pelin Mutlu

E-mail

pmutlu@metu.edu.tr

Department

Central Laboratory

ORCID

0000-0001-7970-880X

Scopus Author ID

26032190300

Web of Science Researcher ID

AAZ-6710-2021

Vancomycin Containing PDLLA and PLGA/β-TCP Inhibit Biofilm Formation but Do Not Stimulate Osteogenic Transformation of Human Mesenchymal Stem Cells Kankilic, Berna; Bayramlı, Erdal; KORKUSUZ, PETEK; EROĞLU, HAKAN; ŞENER, BURÇİN; Mutlu, Pelin; KORKUSUZ, FEZA (2022-07-01) Aims: Chronic osteomyelitis, including implant-related prosthetic joint infection, is extremely difficult to cure. We develop vancomycin containing release systems from poly(d,l-lactide) (PDLLA) and poly(d,l-lactide-co-gly...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Evaluation of methylation profiles of an epidermal growth factor receptor gene in a head and neck squamous cell carcinoma patient group Mutlu, M.; Mutlu, Pelin; Azarkan, S.; Baylr, Ö.; Öcal, B.; Saylam, G.; KORKMAZ, MEHMET HAKAN (2021-03-23) Upregulation of the epidermal growth factor receptor (EGFR) gene has shown an important impact on the development of head and neck cancers due to its important regulation role on multiple cell signaling pathways. The aim o...
Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery PARSIAN, MARYAM; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2016-12-30) Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an adv...
Synthesis of PLGA Coated Magnetic Nanoparticles for Co Delivery of Cancer Drug and Vitamin E TPGS Metin, Esra; Mutlu, Pelin; Gündüz, Ufuk (2016-10-30)
Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug PARSIAN, Maryam; UNSOY, Gozde; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2016-08-05) Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility...
Nek6 nın K562 Hücre Hatlarında Çoklu İlaç Dirençliliği ve Apoptoz Üzerindeki Etkileri Nabioğlu, Ayça; Mutlu, Pelin; Yalçın Azarkan, Serap; Gündüz, Ufuk (null; 2016-02-24)
Gemsitabin Yüklü Yarım Jenerasyon PAMAM Dendrimer Kaplı Manyetik Nanoparçacıkların Meme Kanseri Hücre Hatları Üzerindeki Sitotoksik Etkileri Parsian, Maryam; Mutlu, Pelin; Yalçın Azarkan, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (null; 2016-02-24)
Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met Polymorphisms in a Turkish Population and Their Association with the Risk of Chronic Lymphocytic Leukemia Mutlu, Pelin; Yildirim, Murat; Nevruz, Oral; Cetin, Ahmet Turker; Avcu, Ferit (2015-09-01) DNA repair systems are essential for cellular functions. Defects due to sequence variations in DNA repair genes can lead severe failure of cell functions and causing many cancer types including leukemia. The aim of this st...
Magnetic Half Generation PAMAM Dendrimeric Nanoparticles for Targeting Delivery of Gemcitabine Maryam, Parsian; Mutlu, Pelin; Yalçın Azarkan, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2015-06-09) Antitumor activity of Gemcitabine, a nucleoside analogue, has been reported in a variety of human tumors, including breast cancer in both experimental and clinical studies. Conventional chemotherapeutic agents are unspecif...

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