Pelin Mutlu

E-mail

pmutlu@metu.edu.tr

Department

Central Laboratory

ORCID

0000-0001-7970-880X

Scopus Author ID

26032190300

Web of Science Researcher ID

AAZ-6710-2021

Vancomycin Containing PDLLA and PLGA/β-TCP Inhibit Biofilm Formation but Do Not Stimulate Osteogenic Transformation of Human Mesenchymal Stem Cells Kankilic, Berna; Bayramlı, Erdal; KORKUSUZ, PETEK; EROĞLU, HAKAN; ŞENER, BURÇİN; Mutlu, Pelin; KORKUSUZ, FEZA (2022-07-01) Aims: Chronic osteomyelitis, including implant-related prosthetic joint infection, is extremely difficult to cure. We develop vancomycin containing release systems from poly(d,l-lactide) (PDLLA) and poly(d,l-lactide-co-gly...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Evaluation of methylation profiles of an epidermal growth factor receptor gene in a head and neck squamous cell carcinoma patient group Mutlu, M.; Mutlu, Pelin; Azarkan, S.; Baylr, Ö.; Öcal, B.; Saylam, G.; KORKMAZ, MEHMET HAKAN (2021-03-23) Upregulation of the epidermal growth factor receptor (EGFR) gene has shown an important impact on the development of head and neck cancers due to its important regulation role on multiple cell signaling pathways. The aim o...
Doxorubicin-loaded magnetic nanoparticles downregulate expression of anti-apoptotic genes in resistant breast cancer cells. Yalçın Azarkan, Serap; Mutlu, Pelin; Ünsoy, Gözde; Khodadust, Rouhollah; Gündüz, Ufuk (2020-06-01)
Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery Parsian, Maryam; Mutlu, Pelin; Yalcin, Serap; Gündüz, Ufuk (2020-01-01) Background: Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic moie...
Targeting ability and internalization of gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles on breast cáncer cell lines. Parsian, Maryam; Mutlu, Pelin; Yalçın Azarkan, Serap; Gündüz, Ufuk (null; 2018-10-14)
Polyhydroxybutyrate (Phb) Coated Magnetic Nanoparticles For Targeting Delivery of Gemcitabine. Parsian, Maryam; Mutlu, Pelin; Yalçın Azarkan, Serap; Gündüz, Ufuk (null; 2018-04-27)
DETERMINATION OF THE RELATIONSHIP BETWEEN DOXORUBICIN RESISTANCE AND WNT SIGNALING PATHWAY IN HELA AND K562 CELL LINES Mutlu, Pelin; Pourianazar, Negar Taghavi; Yucel, Meral; Gündüz, Ufuk (2018-01-01) Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activit...
Co-delivery of Doxorubicin and D-alpha-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles Metin, Esra; Mutlu, Pelin; Gündüz, Ufuk (2018-01-01) Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, no...

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