Ufuk Gündüz

E-mail

ufukg@metu.edu.tr

Department

Differential synergistic effects of palbociclib and doxorubicin on doxorubicin-resistant cancer cells with diverse tumor origins Yalcin, Gizem Damla; MUTLU, PELİN; Kazan, Hasan Huseyin; Gündüz, Ufuk (2024-01-01) Palbociclib is a dual inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). Palbociclib has frequently been studied in breast cancer cells and has also been linked to function of P-glycoprotein (P-gp), main protein respo...
Investigation of the Therapeutic Effects of Palbociclib Conjugated Magnetic Nanoparticles on Different Types of Breast Cancer Cell Lines Parsian, Maryam; MUTLU, PELİN; Taghavi Pourianazar, Negar; Yalcin Azarkan, Serap; Gündüz, Ufuk (2023-01-01) Introduction: Drug targeting and controlled drug release systems in cancer treatment have many advantages over conventional chemotherapy in terms of limiting systemic toxicity, side effects, and overcoming drug resistance....
Development of a microfluidic platform to maintain viability of micro-dissected tumor slices in culture Parsian, Maryam; MUTLU, PELİN; Yıldırım, Ender; Ildiz, Can; Özen, Can; Gündüz, Ufuk (2022-05-01) © 2022 Author(s).One of the issues limiting the development of personalized medicine is the absence of realistic models that reflect the nature and complexity of tumor tissues. We described a new tissue culture approach th...
Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme Yalcin, Serap; Gündüz, Ufuk (2021-03-01) Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was...
Topical delivery of heparin from PLGA nanoparticles entrapped in nanofibers of sericin/gelatin scaffolds for wound healing Basaran, Duygu Deniz Akolpoglu; Gündüz, Ufuk; Tezcaner, Ayşen; Keskin, Dilek (2021-03-01) Skin regeneration is one of the most important issues in tissue engineering. Research on more effective biomaterials that will enhance regeneration while enabling requirements of a healing skin site is an important challen...
Poly (I:C)- and doxorubicin-loaded magnetic dendrimeric nanoparticles affect the apoptosis-related gene expressions in MCF-7 cells Khodadust, Rouhollah; Alpsoy, Aktan; Ünsoy, Gözde; Gündüz, Ufuk (The Scientific and Technological Research Council of Turkey, 2020-8-19) Use of nanoparticles as drug carrier vectors has great potential to circumvent the limitations associated with chemotherapy, including drug resistance and destructive side effects. For this purpose, magnetic generation 4 d...
15-LOX-1 has diverse roles in the resensitization of resistant cancer cell lines to doxorubicin Kazan, Hasan Huseyin; Urfali-Mamatoglu, Cagri; Yalcin, Gizem Damla; Bulut, Onur; Sezer, Abdullah; Banerjee, Sreeparna; Gündüz, Ufuk (2020-05-01) Lipoxygenases (LOXs) are a family of enzymes that can oxygenate polyunsaturated fatty acids. As a member of the family, 15-lipoxygenase-1 (15-LOX-1) specifically metabolizes arachidonic acid and linoleic acid. 15-LOX-1 can...
Fomes fomentarius and Tricholoma anatolicum (Agaricomycetes) Extracts Exhibit Significant Multiple Drug-Resistant Modulation Activity in Drug-Resistant Breast Cancer Cells DOĞAN, HASAN HÜSEYİN; Kars, Meltem Demirel; Ozdemir, Ozdem; Gündüz, Ufuk (2020-01-01) Multiple drug resistance is one of the main problems that hinder successful cancer chemotherapy. Investigations on the development of effective chemotherapeutic agents and drug resistance inhibitors motivate studies on the...
Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery Parsian, Maryam; Mutlu, Pelin; Yalcin, Serap; Gündüz, Ufuk (2020-01-01) Background: Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic moie...
Dielectrophoretic detection of imatinib resistance in K562 Cells Using A lab-on-a-chip system Demircan Yalçın, Yağmur; Toral, Taylan Berkın; Sukaş, Serkan; Yıldırım, Ender; Zorlu, Özge; Gündüz, Ufuk; Külah, Haluk (Chemical and Biological Microsystems Society (CBMS); 2019-10-27) This study presents label-free detection of imatinib resistance in K562 cells via integrated dielectrophoretic detection and impedimetric counting on a lab-on-a-chip system. Two impedimetric counting units were placed upst...

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