Erkan Kiriş

E-mail

ekiris@metu.edu.tr

Department

Department of Biology

ORCID

0000-0003-2095-0460

Scopus Author ID

23008810500

Web of Science Researcher ID

AAZ-6719-2020

Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment Koc, Dilara; Ezgin, Sena; Kavakli, Ebru; Kota, Krishna P.; Sen, Edanur; Mahone, Christopher; Palko, Mary Ellen; Cazares, Lisa H.; Can, Tolga; Tessarollo, Lino; Bavari, Sina; Marıon, Antoıne; Kiriş, Erkan (2025-10-01) Botulinum Neurotoxin Serotype A (BoNT/A), responsible for most human botulism cases, inhibits neurotransmitter release by cleaving the target protein SNAP-25. Previous literature demonstrated that BoNT/A mediated cleavage ...
Astrocytes in Primary Familial Brain Calcification (PFBC): Emphasis on the Importance of Induced Pluripotent Stem Cell-Derived Human Astrocyte Models Kavakli, Ebru; Gul, Nazli; Begentaş, Onur Can; Kiriş, Erkan (2025-01-01) Primary familial brain calcification (PFBC) is a rare, progressive central nervous system (CNS) disorder without a cure, and the current treatment methodologies primarily aim to relieve neurological and psychiatric symptom...
Editorial: Studying rare diseases using induced pluripotent stem cell (iPSC)-based model systems Francis, Kevin R.; Chen, Guokai; Kiriş, Erkan (2025-01-01)
Astrocytes in Primary Familial Brain Calcification (PFBC): Emphasis on the Importance of Induced Pluripotent Stem Cell-Derived Human Astrocyte Models Kavaklı, Ebru; Gül, Nazlı; Begentaş, Onur Can; Kiriş, Erkan (Springer, Cham, 2025-01-01)
Tirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells Koc, Dilara; Ibis, Kubra; Besarat, Peri; BANOĞLU, ERDEN; Kiriş, Erkan (2024-09-01) Botulinum neurotoxins (BoNT) inhibit neuroexocytosis, leading to the potentially lethal disease botulism. BoNT serotype A is responsible for most human botulism cases, and there are no approved therapeutics to treat alread...
Generation and characterization of human induced pluripotent stem cell line METUi002-A from a patient with primary familial brain calcification (PFBC) carrying a heterozygous mutation (c.687dupT (p.Val230CysfsTer28)) in the SLC20A2 gene. Begentas, Onur Can; Koc, Dilara; Sendur, Nuriye Kayali; Besarat, Peri; Ezgin, Sena; Temel, Musa; Bora, Hatice Ayse Tokcaer; Kiriş, Erkan (2023-10-18)
TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior. Yanpallewar, Sudhirkumar; Tomassoni-Ardori, Francesco; Palko, Mary Ellen; Hong, Zhenyi; Kiriş, Erkan; Becker, Jodi; Fulgenzi, Gianluca; Tessarollo, Lino (2022-03-17) Recent studies have suggested that the use of cognitive enhancers as adjuncts to exposure-based therapy in individuals suffering from post-traumatic stress disorder (PTSD) may be beneficial. Brain cholinergic signaling thr...
Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases. Kiriş, Erkan (2021-12-19)
Fare Kök Hücrelerinden Başkalaştırılmış Bazal Ön Beyin Kolinerjik Nöronlarda TrkA Sinyalinin Artırılmasının in vitro Alzheimer Hastalığını Nörodejeneratif Sürecine Karşı Etkisinin Kontrollere Kıyasla Araştırılması Ezgin, Sena; Kiriş, Erkan (2021-11-22)
Amyloid beta peptit oligomerlerinin (Aβ(1-42)) in vitro muamelesinin TrkB sinyali artırılmış kök hücre temelli kortikal nöronlar üzerindeki etkisinin doğal kortikal nöronlar ile kıyaslamalı olarak araştırılması Beşarat, Peri; Ezgin, Sena; Kiriş, Erkan (2021-11-22)

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