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Mehmet Somel

Department of Biology
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Temporal changes in the gene expression heterogeneity during brain development and aging
Isildak, Ulas; Somel, Mehmet; Thornton, Janet M.; Donertas, Handan Melike (Springer Science and Business Media LLC, 2020-03-01)
Cells in largely non-mitotic tissues such as the brain are prone to stochastic (epi-)genetic alterations that may cause increased variability between cells and individuals over time. Although increased interindividual hete...
Molecular footprint of Medawar's mutation accumulation process in mammalian aging
Turan, Zeliha Gozde; Parvizi, Poorya; Donertas, Handan Melike; Tung, Jenny; Khaitovich, Philipp; Somel, Mehmet (2019-08-01)
Medawar's mutation accumulation hypothesis explains aging by the declining force of natural selection with age: Slightly deleterious germline mutations expressed in old age can drift to fixation and thereby lead to aging-r...
Ancient Mitochondrial Genomes Reveal the Absence of Maternal Kinship in the Burials of catalhoyuk People and Their Genetic Affinities
Chylenski, Maciej; Ehler, Edvard; Somel, Mehmet; Yaka, Reyhan; Krzewinska, Maja; Dabert, Miroslawa; Juras, Anna; Marciniak, Arkadiusz (MDPI AG, 2019-03-11)
catalhoyuk is one of the most widely recognized and extensively researched Neolithic settlements. The site has been used to discuss a wide range of aspects associated with the spread of the Neolithic lifestyle and the soci...
An Archaeogenomic Investigation of Consanguinity During the Neolithic Transition
Taskent, Recep O.; Sumer, Arev P.; Koptekin, Dilek; Ozkan, Mustafa; Ceballos, Francisco C.; Gokcumen, Omer; Somel, Mehmet (2019-03-01)
Genomic and Strontium Isotope Variation Reveal Immigration Patterns in a Viking Age Town
Krzewinska, Maja; Kjellstrom, Anna; Guenther, Torsten; Hedenstierna-Jonson, Charlotte; Zachrisson, Torun; Omrak, Ayca; Yaka, Reyhan; Kilinc, Gulsah Merve; Somel, Mehmet; Sobrado, Veronica; Evans, Jane; Knipper, Conine; Jakobsson, Mattias; Stora, Jan; Gotherstrom, Anders (Elsevier BV, 2018-09-10)
The impact of human mobility on the northern European urban populations during the Viking and Early Middle Ages and its repercussions in Scandinavia itself are still largely unexplored. Our study of the demographics in the...
Investigating Holocene human population history in North Asia using ancient mitogenomes
Kilinc, Gulsah Merve; Kashuba, Natalija; Yaka, Reyhan; Sumer, Arev Pelin; Yuncu, Eren; Shergin, Dmitrij; Ivanov, Grigorij Leonidovich; Kichigin, Dmitrii; Pestereva, Kjunnej; Volkov, Denis; Mandryka, Pavel; Kharinskii, Artur; Tishkin, Alexey; Ineshin, Evgenij; Kovychev, Evgeniy; Stepanov, Aleksandr; Alekseev, Aanatolij; Fedoseeva, Svetlana Aleksandrovna; Somel, Mehmet; et.al. (Springer Science and Business Media LLC, 2018-06-12)
Archaeogenomic studies have largely elucidated human population history in West Eurasia during the Stone Age. However, despite being a broad geographical region of significant cultural and linguistic diversity, little is k...
Archaeogenetics of Late Iron Age Cemialo Srt, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic
Yaka, Reyhan; Birand, Aysegul; Yilmaz, Yasemin; Caner, Ceren; Acan, Sinan Can; Gunduzalp, Sidar; Parvizi, Poorya; Ozdogan, Asli Erim; Togan, Inci; Somel, Mehmet (2018-05-01)
ObjectivesNorth Mesopotamia has witnessed dramatic social change during the Holocene, but the impact of these events on its demographic history is poorly understood. Here, we study this question by analysing genetic data f...
Variation and Functional Impact of Neanderthal Ancestry in Western Asia
Taskent, Recep Ozgur; Alioglu, Nursen Duha; Fer, Evrim; Donertas, Handan Melike; Somel, Mehmet; Gokcumen, Omer (2017-12-01)
Neanderthals contributed genetic material to modern humans via multiple admixture events. Initial admixture events presumably occurred in Western Asia shortly after humans migrated out of Africa. Despite being a focal poin...
Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean
Kilinc, Gulsah Merve; KOPTEKIN, Dilek; Atakuman, Çiğdem; SUMER, Arev Pelin; DONERTAS, Handan Melike; YAKA, Reyhan; Bilgin, Cemal Can; BÜYÜKKARAKAYA, ALİ METİN; Baird, Douglas; ALTINISIK, Ezgi; FLEGONTOV, Pavel; Gotherstrom, Anders; TOGAN, Inci; Somel, Mehmet (2017-11-29)
The Neolithic transition in west Eurasia occurred in two main steps: the gradual development of sedentism and plant cultivation in the Near East and the subsequent spread of Neolithic cultures into the Aegean and across Eu...
Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity
Donertas, Handan Melike; İzgi, Hamit; Kamacioglu, Altug; He, Zhisong; Khaitovich, Philipp; Somel, Mehmet (2017-07-19)
It was previously reported that mRNA expression levels in the prefrontal cortex at old age start to resemble pre-adult levels. Such expression reversals could imply loss of cellular identity in the aging brain, and provide...