Merve Akkulak

E-mail

makkulak@metu.edu.tr

Department

Department of Biology

ORCID

0000-0003-2834-7682

Web of Science Researcher ID

AAZ-7025-2020

Modulation of Caco-2 Colon Cancer Cell Viability and CYP2W1 Gene Expression by Hesperidin-treated Lacticaseibacillus rhamnosus GG (LGG) Cell-free Supernatants. Akkulak, Merve; Evin, Emre; Durukan, Ozlem; Celebioglu, Hasan Ufuk; Adali, Orhan (2023-12-06)
Investigating the role of CYP4X1 gene during brain tumor angiogenesis via RNAi mediated gene repression Durukan, Özlem; Akkulak, Merve; Evin, Emre; Adalı, Orhan (2022-10-30)
ONKOFETAL CYP2W1 GENİNİN EPİTELYAL-MEZENKİMAL GEÇİŞ BELİRTEÇLERİ ÜZERİNE ETKİLERİ Akkulak, Merve; Durukan, Özlem; Evin, Emre; Adalı, Orhan (2022-10-30) Sitokrom P450 2W1 (CYP2W1) expresyonu, fetal ve tümör dokularında çok yüksek olmasına rağmen sağlıklı yetişkin dokularında saptanamaz veya çok düşüktür. CYP2W1 ekspresyonu, daha agresif tümör fenotipi ile pozitif ilişkili ...
Xenogenic Neural Stem Cell-Derived Extracellular Nanovesicles Modulate Human Mesenchymal Stem Cell Fate and Reconstruct Metabolomic Structure DERKUŞ, BURAK; Isik, Melis; Eylem, Cemil Can; ERGİN, İREM; Camci, Can Berk; Bilgin, Sila; ELBÜKEN, ÇAĞLAR; ARSLAN, YAVUZ EMRE; Akkulak, Merve; Adalı, Orhan; KIRAN, FADİME; Okesola, Babatunde O.; NEMUTLU, EMİRHAN; EMREGÜL, EMEL (2022-03-01) Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to ...
Association of cholesterol 7 alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population SEZER, EDA; CAN DEMİRDÖĞEN, BİRSEN; Demirkaya, Seref; Bulut, Giray; Akkulak, Merve; EVİN, EMRE; Adalı, Orhan (2021-09-01) Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7 alpha-hydr...
Effect of cisplatin treatment on protein expression of vitamin D metabolizing CYP24A1 in PC3 cell line Evin, Emre; Akkulak, Merve; Adalı, Orhan (2018-07-01)
Effect of quercetin on mRNA and protein expressions of vitamin D metabolizing CYP27B1 and CYP24A1 in human embryonic kidney cell line (HEK-293) Durukan, Özlem; Akkulak, Merve; Özhan, Güneş; Evin, Emre; Adalı, Orhan (Wiley, 2018-07-01) Vitamin D is essential compound for life having role not only in the regulation of calcium metabolism but also in the regulation of cell proliferation, immune responses, cardiovascular homeostasis and nervous system. These...
Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatinmetformin combination treatment Durukan, Özlem; Akkulak, Merve; Evin, Emre; Arslan, Şevki; Adalı, Orhan (null; 2018-07-01) Metformin is an antidiabetic drug with anticancer properties. Cisplatin is known as one of the most potent chemotherapeutics for treatment of various types of cancer. In order to overcome cisplatin resistance and toxicity,...
Analysis of Protein and mRNA Expressions of CYP1A1 and CYP2E1 Enzymes In Liver, Colon And Prostate Cancer Cell Lines to Study Drug and Carcinogen Metabolism Evin, Emre; Akkulak, Merve; Adalı, Orhan (null; 2017-10-29) Most of the marketed drugs are metabolized by Cytochrome P450s (CYPs) known as phase I enzymes. A phase I enzyme, CYP1A1 catalyzes the conversion of many pro-carcinogens and hydroxylation of many endogenous substrates. CYP...
Metformin-Cisplatin combination treatment alters gene and protein expressions of CYP17A1 in LNCaP cell line Durukan, Özlem; Akkulak, Merve; Sena Gjota, Ergin; Arslan, Şevki; Adalı, Orhan (null; 2017-06-28)

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