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Merve Akkulak
E-mail
makkulak@metu.edu.tr
Department
Department of Biology
ORCID
0000-0003-2834-7682
Web of Science Researcher ID
AAZ-7025-2020
Publications
Theses Advised
Open Courses
Projects
Modulation of Caco-2 Colon Cancer Cell Viability and CYP2W1 Gene Expression by Hesperidin-treated Lacticaseibacillus rhamnosus GG (LGG) Cell-free Supernatants.
Akkulak, Merve; Evin, Emre; Durukan, Ozlem; Celebioglu, Hasan Ufuk; Adali, Orhan (2023-12-06)
ONKOFETAL CYP2W1 GENİNİN EPİTELYAL-MEZENKİMAL GEÇİŞ BELİRTEÇLERİ ÜZERİNE ETKİLERİ
Akkulak, Merve; Durukan, Özlem; Evin, Emre; Adalı, Orhan (2022-10-30)
Sitokrom P450 2W1 (CYP2W1) expresyonu, fetal ve tümör dokularında çok yüksek olmasına rağmen sağlıklı yetişkin dokularında saptanamaz veya çok düşüktür. CYP2W1 ekspresyonu, daha agresif tümör fenotipi ile pozitif ilişkili ...
Investigating the role of CYP4X1 gene during brain tumor angiogenesis via RNAi mediated gene repression
Durukan, Özlem; Akkulak, Merve; Evin, Emre; Adalı, Orhan (2022-10-30)
Xenogenic Neural Stem Cell-Derived Extracellular Nanovesicles Modulate Human Mesenchymal Stem Cell Fate and Reconstruct Metabolomic Structure
DERKUŞ, BURAK; Isik, Melis; Eylem, Cemil Can; ERGİN, İREM; Camci, Can Berk; Bilgin, Sila; ELBÜKEN, ÇAĞLAR; ARSLAN, YAVUZ EMRE; Akkulak, Merve; Adalı, Orhan; KIRAN, FADİME; Okesola, Babatunde O.; NEMUTLU, EMİRHAN; EMREGÜL, EMEL (2022-03-01)
Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to ...
Association of cholesterol 7 alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population
SEZER, EDA; CAN DEMİRDÖĞEN, BİRSEN; Demirkaya, Seref; Bulut, Giray; Akkulak, Merve; EVİN, EMRE; Adalı, Orhan (2021-09-01)
Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7 alpha-hydr...
Effect of quercetin on mRNA and protein expressions of vitamin D metabolizing CYP27B1 and CYP24A1 in human embryonic kidney cell line (HEK-293)
Durukan, Özlem; Akkulak, Merve; Özhan, Güneş; Evin, Emre; Adalı, Orhan (Wiley, 2018-07-01)
Vitamin D is essential compound for life having role not only in the regulation of calcium metabolism but also in the regulation of cell proliferation, immune responses, cardiovascular homeostasis and nervous system. These...
Alteration of protein and gene expressions of Hexokinase II in PC3 cell lines by cisplatinmetformin combination treatment
Durukan, Özlem; Akkulak, Merve; Evin, Emre; Arslan, Şevki; Adalı, Orhan (null; 2018-07-01)
Metformin is an antidiabetic drug with anticancer properties. Cisplatin is known as one of the most potent chemotherapeutics for treatment of various types of cancer. In order to overcome cisplatin resistance and toxicity,...
Effect of cisplatin treatment on protein expression of vitamin D metabolizing CYP24A1 in PC3 cell line
Evin, Emre; Akkulak, Merve; Adalı, Orhan (2018-07-01)
Analysis of Protein and mRNA Expressions of CYP1A1 and CYP2E1 Enzymes In Liver, Colon And Prostate Cancer Cell Lines to Study Drug and Carcinogen Metabolism
Evin, Emre; Akkulak, Merve; Adalı, Orhan (null; 2017-10-29)
Most of the marketed drugs are metabolized by Cytochrome P450s (CYPs) known as phase I enzymes. A phase I enzyme, CYP1A1 catalyzes the conversion of many pro-carcinogens and hydroxylation of many endogenous substrates. CYP...
Effect of resveratrol on mRNA and protein expressions of Vitamin D metabolizing CYP24A1 in human embryonic kidney cell line (HEK-293)
Akkulak, Merve; Evin, Emre; Adalı, Orhan (null; 2017-06-28)
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