Müslüm İlgü

E-mail

ilgu@metu.edu.tr

Department

Department of Biology

ORCID

0000-0003-1558-462X

Scopus Author ID

55644398900

Web of Science Researcher ID

AAZ-8031-2020

Rapid Nanoplasmonic-Enhanced Detection of SARS-CoV-2 and Variants on DNA Aptamer Metasurfaces TORUN, HÜLYA; Bilgin, Buse; İlgü, Müslüm; Batur, Numan; Ozturk, Meric; Barlas, Tayfun; Guney-Esken, Gulen; Yanik, Cenk; Celik, Suleyman; Dogan, Ozlem; Ergonul, Onder; Can, Fusun; Solaroglu, Ihsan; Onbasli, Mehmet C. (2023-04-01) Since the discovery of coronavirus disease 2019 (COVID-19) in December 2019, it has been mainly diagnosed with quantitative reverse transcription polymerase chain reaction (PCR) of nasal swabs in clinics. A very sensitive ...
Clinical validation of SERS metasurface SARS-CoV-2 biosensor Bilgin, Buse; Torun, Hülya; İlgü, Müslüm; Yanik, Cenk; Batur, Sükrü Numan; Çelik, Süleyman; Öztürk, Meriç; Dogan, Özlem; Ergönül, Önder; Solaroglu, Ihsan; Can, Füsun; Onbasli, Mehmet Cengiz (2022-01-01) © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.The real-Time polymerase chain reaction (RT-PCR) analysis using nasal swab samples is the gold standard approach for COVID-19 diagnosis. Howe...
Aptamer Applications in Neuroscience Ozturk, Meric; Nilsen-Hamilton, Marit; İlgü, Müslüm (2021-12-01) Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epile...
Sampling Performance of Multiple Independent Molecular Dynamics Simulations of an RNA Aptamer Yan, Shuting; Peck, Jason M.; İlgü, Müslüm; Nilsen-Hamilton, Marit; Lamm, Monica H. (2020-08-01) Using multiple independent simulations instead of one long simulation has been shown to improve the sampling performance attained with the molecular dynamics (MD) simulation method. However, it is generally not known how l...
Common Secondary and Tertiary Structural Features of Aptamer-Ligand Interaction Shared by RNA Aptamers with Different Primary Sequences İlgü, Müslüm; Khounlo, Ryan M.; Lamm, Monica H.; Nilsen-Hamilton, Marit (MDPI AG, 2019-12-01) Aptamer selection can yield many oligonucleotides with different sequences and affinities for the target molecule. Here, we have combined computational and experimental approaches to understand if aptamers with different s...
Aptamer-enabled uptake of small molecule ligands Auwardt, Supipi Liyamali; Seo, Yeon-Jung; İlgü, Müslüm; Ray, Judhajeet; Feldges, Robert R.; Shubham, Shambhavi; Bendickson, Lee; Levine, Howard A.; Nilsen-Hamilton, Marit (Springer Science and Business Media LLC, 2018-10-24) The relative ease of isolating aptamers with high specificity for target molecules suggests that molecular recognition may be common in the folds of natural RNAs. We show here that, when expressed in cells, aptamers can in...
Specificity and Ligand Affinities of the Cocaine Aptamer: Impact of Structural Features and Physiological NaCl Sachan, Ashish; İlgü, Müslüm; Kempema, Aaron; Kraus, George A.; Nilsen-Hamilton, Marit (American Chemical Society (ACS), 2016-08-02) The cocaine aptamer has been seen as a good candidate for development as a probe for cocaine in many contexts. Here, we demonstrate that the aptamer binds cocaine, norcocaine, and cocaethylene with similar affinities and a...
Light-up and FRET aptamer reporters; evaluating their applications for imaging transcription in eukaryotic cells İlgü, Müslüm; BENDICKSON, Lee; WANG, Tianjiao; Geraskin, Ivan M.; Kraus, George A.; Nilsen-Hamilton, Marit (Elsevier BV, 2016-04-01) The regulation of RNA transcription is central to cellular function. Changes in gene expression drive differentiation and cellular responses to events such as injury. RNA trafficking can also have a large impact on protein...
IMAGEtags: Quantifying mRNA Transcription in Real Time with Multiaptamer Reporters Ray, J.; SHIN, I.; İlgü, Müslüm; BENDICKSON, L.; GUPTA, V.; KRAUS, G. A.; NILSEN-HAMILTON, M. (2016-01-01) Cell communications are essential to the organization, development, and maintenance of multicellular organisms. Much of this communication involves changes in RNA transcription and is dynamic. Most methods for studying tra...
Aptamers in analytics İlgü, Müslüm (2016-01-01) Nucleic acid aptamers are promising alternatives to antibodies in analytics. They are generally obtained through an iterative SELEX protocol that enriches a population of synthetic oligonucleotides to a subset that can rec...

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