Nurcan Tunçbağ

E-mail

ntuncbag@metu.edu.tr

Department

Graduate School of Informatics

ORCID

0000-0002-0389-9459

Scopus Author ID

23478859800

Unveiling hidden connections in omics data via pyPARAGON: an integrative hybrid approach for disease network construction Arici, Muslum Kaan; Tunçbağ, Nurcan (2024-09-01) Network inference or reconstruction algorithms play an integral role in successfully analyzing and identifying causal relationships between omics hits for detecting dysregulated and altered signaling components in various ...
BioNet-XR: Biological Network Visualization Framework for Virtual Reality and Mixed Reality Environments Şenderin, Büşra; Tunçbağ, Nurcan; Sürer, Elif (2024-02-01) Protein-protein interaction networks (PPIN) enable the study of cellular processes in organisms. Visualizing PPINs in extended reality (XR), including virtual reality (VR) and mixed reality (MR), is crucial for exploring s...
Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide Nussinov, Ruth; Yavuz, Bengi Ruken; Demirel, Habibe Cansu; Arici, M. Kaan; Jang, Hyunbum; Tunçbağ, Nurcan (2024-01-01) The connection and causality between cancer and neurodevelopmental disorders have been puzzling. How can the same cellular pathways, proteins, and mutations lead to pathologies with vastly different clinical presentations?...
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome Yavuz, Bengi Ruken; Arici, M. Kaan; Demirel, Habibe Cansu; Tsai, Chung-Jung; Jang, Hyunbum; Nussinov, Ruth; Tunçbağ, Nurcan (2023-12-01) Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs) are more prone to develop certain types of cancer. Notably, however, the case statistics can be impacted by late discovery of cancer...
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK Nussinov, Ruth; Yavuz, Bengi Ruken; Arici, M Kaan; Demirel, Habibe Cansu; Zhang, Mingzhen; Liu, Yonglan; Tsai, Chung-Jung; Jang, Hyunbum; Tunçbağ, Nurcan (2023-01-01) Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and mutations. Their clinical symptoms are different. However, individuals with NDDs have higher probabilities of eventually developing cancer. Here,...
Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma Sinoplu, Esra; Tunçbağ, Nurcan; Atalay, Rengül (2022-10-25)
Unveiling the Impact of Cancer Mutations in Phosphosites in Signaling Networks Basaran, Esra; Tunçbağ, Nurcan (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Signal transduction is predominantly mediated by phosphorylation events; however, phosphosites are inhibited or over-activated in cancer tissues. In this study, we focused on patient-specific mutations in TCGA that overlap...
Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma Nalbat, Esra; Tunçbağ, Nurcan; Cetin-Atalay, Rengul (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed cancer and a leading cause of death worldwide. The hyperactivated cell survival signaling pathways cause resistance to conventional chemotherapeutics so t...
KRas4B Conformational Differences are Highlighted by Computational Analysis with GNM-ANM Eren, Meryem; Tunçbağ, Nurcan; Nussinov, Ruth; Jang, Hyunbum; Gursoy, Attila; Keskin, Özlem (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Ras GTPase has critical functions in cellular signaling. Rasrelated human cancers form as a result of disrupted interactions with its regulators and effectors. Our aim is to aid in targeting these disrupted mechanisms by u...
Comparative biological network analysis for differentially expressed proteins as a function of bacilysin biosynthesis in Bacillus subtilis Kutnu, Meltem; İşlerel, Elif Tekin; Tunçbağ, Nurcan; Özcengiz, Gülay (2022-08-03) © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.The Gram-positive bacterium Bacillus subtilis produces a diverse range of seconda...

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