Nülüfer Tülün Güray

E-mail

guray@metu.edu.tr

Department

Department of Biology

ORCID

0000-0003-4572-1429

Scopus Author ID

57217086164

Web of Science Researcher ID

AAZ-6727-2020

Identification of Potential Therapeutic Genes and Pathways in Phytoestrogen Emodin Treated Breast Cancer Cell Lines via Network Biology Approaches Sakalli-Tecim, Elif; Uyar-Arpaci, Pembegul; Güray, Nülüfer Tülün (2021-02-01) Phytoestrogens have been investigated for their potential anti-tumorigenic effects in various cancers including breast cancer. Emodin being a phytoestrogen shows anti-carcinogenic properties especially in estrogen receptor...
In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration Tombuloğlu, Ayşegül; Çöpoğlu, Hülya; Aydın Son, Yeşim; Güray, Nülüfer Tülün (2020-12-01) Boron is a prominent part of the human diet and one of the essential trace elements for humans. Dietary boron is mostly transformed into boric acid within the body and has been associated with desirable health outcomes. No...
EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses BRCA1-mutated breast cancer Asik, Elif; Akpinar, Yeliz; Caner, Ayse; Kahraman, Nermin; Güray, Nülüfer Tülün; Volkan, Mürvet; Albarracins, Constance; Pataer, Apar; Arun, Banu; Ozpolat, Bulent (Future Medicine Ltd, 2019-09-01) Aim: To investigate the role of EF2K in BRCA1-mutated breast cancer. Materials & methods: We developed silica coated cobalt-ferrite (CoFe) nanoparticles for in vivo delivery of small interfering RNAs (siRNAs) into BRCA1-mu...
Differential expressions and functions of phosphodiesterase enzymes in different regions of the rat heart DERİCİ, MEHMET KÜRŞAT; SADİ, GÖKHAN; Cenik, Basar; Güray, Nülüfer Tülün; DEMİREL YILMAZ, EMİNE (Elsevier BV, 2019-02-05) Phosphodiesterase enzymes (PDEs) are responsible for the adjustment of cyclic nucleotide levels. Alterations in PDE expressions in different tissues cause conflicts between functional and clinical effects of PDE inhibitors...
Network models for understanding boron-induced transcriptomics changes within HepG2 cell line Tombuloğlu, Ayşegül; Çöpoğlu, Hülya; Güray, Nülüfer Tülün; Son Aydın, Yeşim (null; 2018-10-25) Boron has crucial roles in plant growth and survival; also, it is suggested as an essential trace element forhuman physiology. Accumulating evidence show beneficial effects of boron for human health. Along withits benefits...
Cellular uptake and apoptotic potential of rhenium labeled magnetic protein cages in MDA-MB-231 cells Asik, Elif; Aslan, Tugba Nur; Güray, Nülüfer Tülün; Volkan, Mürvet (Elsevier BV, 2018-10-01) Re-188-magnetoferritin nanoparticles (NPs) provide an attractive platform for localized radiation therapy due to their magnetic targeting capability while enhancing contrast in magnetic resonans imaging (MRI) signals. In t...
Genetic control of 4 coumarate coenzyme A ligase (4CL9 enzymes involved in lignin biosynthesis of European black poplar (Populus nigra L.) Taşkıran, Bircan; Güray, Nülüfer Tülün; Kaya, Zeki (null; 2018-01-13) European black poplar (Populus nigra L.) is considered as one of the most economically significant forest trees with respect to production of wood, pulp, bioenergy and other wood-based products. The content and quality of ...
MODULATION OF CYTOCHROME P450s AND ANTIOXIDANT ENZYMES BY CAFFEIC ACID, p-COUMARIC ACID AND QUERCETIN-RICH ANATOLIAN PROPOLIS IN HUMAN ADENOCARCINOMA HT-29 CELLS ALTAY, AHMET; İrtem Kartal, Deniz; Sagdicoglu-Celep, Gulcin; Güray, Nülüfer Tülün; Bozoglu, Faruk (2018-01-01) Propolis, which is a complex resinous material has diverse pharmacological and biological properties. Phase I and II enzymes are responsible for detoxication and elimination of activated carcinogens, acting as important bi...
Eucaryotic elongation factor 2kinaze is a novel therapeutic target in BRCA1 mutated breast cancer Volkan, Mürvet; Güray, Nülüfer Tülün; Ozpolat, Bulent; Kahraman, Nermin (2017-07-01)
Changes in gene profile of human hepatocellular carcinoma cell line (HepG2) induced by boric acid at half mazimal inhibitory concentration (IC50). Tombuloğlu, Ayşegül; Çöpoğlu, Hülya; Güray, Nülüfer Tülün; Aydın Son, Yeşim (null; 2017-06-30) Boron is an essential micronutrient for many biological processes in plants and animals. In humans, adverse health outcomes are reported for both boron deprivation and excessive boron intake. Humans might get exposed to hi...

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