Özgül Persil Çetinkol

E-mail

opersil@metu.edu.tr

Department

Department of Chemistry

ORCID

0000-0002-6632-6981

Scopus Author ID

25722721800

Web of Science Researcher ID

AAZ-6526-2020

Electrochemical detection of Oxaliplatin induced DNA damage in G-quadruplex structures Osmanoğulları, Sıla Can; FOROUGH, MEHRDAD; Persil Çetinkol, Özgül; UDUM, YASEMİN; Toppare, Levent Kamil (2023-06-15) Oxaliplatin (OXP) is a platinum-based chemotherapeutic agent that induces DNA damage by forming intra- and interstrand crosslinks, mainly at the N7s of adenine (A) and guanine (G) bases. In addition to double-stranded DNA,...
Disposable paper-based sensors Bilgen, Ecenaz; Suvaci, Zeynep; Persil Çetinkol, Özgül; Forough, Mehrdad (Elsevier Science, Oxford/Amsterdam , 2023-03-01) Paper-based sensors provide valuable advantages such as availability, flexibility, simplicity, biocompatibility, cost-effectiveness, and portability for rapid single-point measurement/detection of a wide range of analytes ...
Coumarin 6H-fused fluorescent probe for highly sensitive detection of coralyne using oligonucleotide-modified silver nanoparticles Usta, Hatice Müge; Forough, MEHRDAD; Persil Çetinkol, Özgül (2022-08-01) In this study, a novel, rapid, and sensitive fluorescence sensing platform was developed for the detection of coralyne (COR) by the conjugation of coumarin 6H (C6H) fluorescent dye with oligonucleotide-modified silver nano...
Highly-sensitive and fast detection of human telomeric G-Quadruplex DNA based on a hemin-conjugated fluorescent metal-organic framework platform Javan Kouzegaran, Vahid; Farhadi, Khalil; Forough, Mehrdad; Bahram, Morteza; Persil Çetinkol, Özgül (Elsevier BV, 2021-04-15) © 2021 Elsevier B.V.The formation of G-quadruplex (G4) structures in Human telomeric DNA (H-Telo) has been demonstrated to inhibit the activity of telomerase enzyme that is associated with the proliferation of many cancer ...
Doxorubicin exhibits strong and selective association with VEGF Pu22 G-quadruplex Bilgen, Ecenaz; Persil Çetinkol, Özgül (Elsevier BV, 2020-12-01) Background: Vascular endothelial growth factor (VEGF), is upregulated in tumor cells and thus became a potential therapeutic target for anti-cancer drugs. Recent reports suggested the use of Doxorubicin (Dox) with VEGF-tar...
Construction of amperometric biosensor modified with conducting polymer/carbon dots for the analysis of catechol Yasa, Mustafa; Deniz, Aybuke; Forough, Mehrdad; Yildirim, Erol; Persil Çetinkol, Özgül; Udum, Yasemin Arslan; Toppare, Levent Kamil (Wiley, 2020-10-21) Phenolic compounds used in food industries and pesticide industry, are environmentally toxic and pollute the rivers and ground water. For that reason, detection of phenolic compounds such as catechol by using simple, effic...
A conjugated gold nanoparticle-azacyanine off-on-off fluorescence probe for sensitive and selective detection of G-quadruplexes Bilgen, Ecenaz; Forough, Mehrdad; Persil Çetinkol, Özgül (Elsevier BV, 2020-09-01) G-quadruplex secondary structures have gained significant recognition due to the discovery of their involvement in regulation of gene expression and their association with many diseases such as cancer and neurological diso...
Novel Fluorescent Azacyanine Compounds: Improved Synthesis and Optical Properties Doğan, Kübra; Forough, M; Persil Çetinkol, Özgül (2020-09-01) Benzothiazoles are known to possess a number of biological activities and therefore are considered to be an important scaffold in the design and synthesis of pharmacophores. In this study, an improved synthesis method for ...
Azacyanines as Novel Topoisomerase II Alpha Inhibitors Guloglu, Sercan; Kirmaci, Fahriye Nur; Persil Çetinkol, Özgül; Forough, Mehrdad; Gulkaya, Aybuke (Bentham Science Publishers Ltd., 2020-01-01) Introduction: Topoisomerase II alpha (Topo II alpha) has become one of the extensively exploited targets in chemotherapy due to its role in regulating the topological constraints of DNA during replication and transcription...
A DNA-free colorimetric probe based on citrate-capped silver nanoparticles for sensitive and rapid detection of coralyne Usta, Hatice Muge; Forough, Mehrdad; Persil Çetinkol, Özgül (Elsevier BV, 2019-11-01) This paper presents a simple, sensitive and reliable strategy for the colorimetric determination of coralyne (COR) using citrate-capped silver nanoparticles (Cit-AgNPs). In the presence of NaC1, COR induces the aggregation...

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