Altuğ Özçelikkale

E-mail

aozcelik@metu.edu.tr

Department

Department of Mechanical Engineering

ORCID

0000-0002-1783-4445

Scopus Author ID

54972309800

Web of Science Researcher ID

ABA-2198-2020

Microstructure-Level Investigation of Nanoparticle Transport in Collagen Hydrogels for Advancing Nanomedicine Design and Delivery Strategies Akalin, Ali Aykut; Dağıstan, Ege; Özçelikkale, Altuğ (2026-02-17) The clinical translation of nanomedicine is often hindered by inefficient delivery, with the dense extracellular matrix (ECM) posing a significant physical barrier to transport. A predictive understanding of how nanopartic...
Implementation of Microfluidic FRAP for Characterization of Nanoparticle Transport in Porous Biopolymer Networks Dağıstan, Ege; Esmaeilzadeh, Pouriya; Büküşoğlu, Emre; Özçelikkale, Altuğ (2025-08-28) Nanomedicine features nanoparticles (NPs) that can be designed in various sizes, shapes and surface functionalities for therapeutic or diagnostic applications. Despite the major promise of nanomedicine for targeted drug d...
Implementation of Microfluidic FRAP for Characterization of Nanoparticle Transport in Porous Biopolymer Networks Dağıstan, Ege; Esmaeilzadeh, Pouriya; Büküşoğlu, Emre; Özçelikkale, Altuğ (2025-08-28) Nanomedicine features nanoparticles (NPs) that can be designed in various sizes, shapes and surface functionalities for therapeutic or diagnostic applications. Despite the major promise of nanomedicine for targeted drug d...
Implementation of Microfluidic FRAP for Characterization of Nanoparticle Transport in Porous Biopolymer Networks Dağıstan, Ege; Esmaeilzadeh, Pouriya; Büküşoğlu, Emre; Özçelikkale, Altuğ (2025-08-28) Nanomedicine features nanoparticles (NPs) that can be designed in various sizes, shapes and surface functionalities for therapeutic or diagnostic applications. Despite the major promise of nanomedicine for targeted drug d...
Exploiting Matrix Stiffness to Overcome Drug Resistance Aydin, Hakan Berk; Özçelikkale, Altuğ; Acar, Ahmet (2024-07-05) Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better trea...
Prototyping of a Microfluidic Mechanochemical Gradient Chip by 3D Printed Molding for In Vitro Drug Testing Fathi, Milad; Mehrasa, Ali; Özçelikkale, Altuğ (2024-06-14)
Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture Aydin, Hakan Berk; Moon, Hye-Ran; Han, Bumsoo; Özçelikkale, Altuğ; Acar, Ahmet (2024-01-01) Microphysiological systems involving microfluidic 3D culture of cancer cells have emerged as a versatile toolkit to study tumor biological problems and evaluate potential treatment strategies. Incorporation of microfluidic...
Capillary pressure barriers for spatial confinement in organ-on-a-chip devices Açıkgöz, Berk Can; Dirmencioğlu, Ufuk; Farahani, Sarah; Özçelikkale, Altuğ; Yıldırım, Ender (2023-05-04)
Modeling and Characterization of Nanomedicine Transport within Tumor Microenvironment across Scales Akalın, Ali Aykut; Özçelikkale, Altuğ (2022-09-19) Despite significant advances in recent decades, diagnosis and treatment of cancer remain to be a major challenge. Advances in nanotechnology have enabled numerous nanoparticle (NP) formulations for efficient delivery of dr...
Migration and 3D Traction Force Measurements inside Compliant Microchannels Afthinos, Alexandros; Bera, Kaustav; Chen, Junjie; Özçelikkale, Altuğ; Amitrano, Alice; Choudhury, Mohammad Ikbal; Huang, Randy; Pachidis, Pavlos; Mistriotis, Panagiotis; Chen, Yun; Konstantopoulos, Konstantinos (2022-09-01) Cells migrate in vivo through channel-like tracks. While polydimethylsiloxane devices emulate such tracks in vitro, their channel walls are impermeable and have supraphysiological stiffness. Existing hydrogel-based platfor...

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