Altuğ Özçelikkale

E-mail

aozcelik@metu.edu.tr

Department

Department of Mechanical Engineering

ORCID

0000-0002-1783-4445

Scopus Author ID

54972309800

Web of Science Researcher ID

ABA-2198-2020

Exploiting Matrix Stiffness to Overcome Drug Resistance Aydin, Hakan Berk; Özçelikkale, Altuğ; Acar, Ahmet (2024-07-05) Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better trea...
Prototyping of a Microfluidic Mechanochemical Gradient Chip by 3D Printed Molding for In Vitro Drug Testing Fathi, Milad; Mehrasa, Ali; Özçelikkale, Altuğ (2024-06-14)
Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture Aydin, Hakan Berk; Moon, Hye-Ran; Han, Bumsoo; Özçelikkale, Altuğ; Acar, Ahmet (2024-01-01) Microphysiological systems involving microfluidic 3D culture of cancer cells have emerged as a versatile toolkit to study tumor biological problems and evaluate potential treatment strategies. Incorporation of microfluidic...
Capillary pressure barriers for spatial confinement in organ-on-a-chip devices Açıkgöz, Berk Can; Dirmencioğlu, Ufuk; Farahani, Sarah; Özçelikkale, Altuğ; Yıldırım, Ender (2023-05-04)
Modeling and Characterization of Nanomedicine Transport within Tumor Microenvironment across Scales Akalın, Ali Aykut; Özçelikkale, Altuğ (2022-09-19) Despite significant advances in recent decades, diagnosis and treatment of cancer remain to be a major challenge. Advances in nanotechnology have enabled numerous nanoparticle (NP) formulations for efficient delivery of dr...
Migration and 3D Traction Force Measurements inside Compliant Microchannels Afthinos, Alexandros; Bera, Kaustav; Chen, Junjie; Özçelikkale, Altuğ; Amitrano, Alice; Choudhury, Mohammad Ikbal; Huang, Randy; Pachidis, Pavlos; Mistriotis, Panagiotis; Chen, Yun; Konstantopoulos, Konstantinos (2022-09-01) Cells migrate in vivo through channel-like tracks. While polydimethylsiloxane devices emulate such tracks in vitro, their channel walls are impermeable and have supraphysiological stiffness. Existing hydrogel-based platfor...
Cytotoxic T Lymphocyte Activation Signals Modulate Cytoskeletal Dynamics and Mechanical Force Generation Pathni, Aashli; Özçelikkale, Altuğ; Rey-Suarez, Ivan; Li, Lei; Davis, Scott; Rogers, Nate; Xiao, Zhengguo; Upadhyaya, Arpita (2022-03-01) Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor o...
Predictive Design and Analysis of Drug Transport by MultiScale Computational Models Under Uncertainty Akalın, Ali Aykut; Dedekargınoğlu, Barış; Choi, Sae Rome; Han, Bumsoo; Özçelikkale, Altuğ (2022-01-01) © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Computational modeling of drug delivery is becoming an indispensable tool for advancing drug development pipel...
Rapid Low-Cost Prototyping of Organ-on-Chip Platforms by 3D-Printed Microfluidics Dedekargınoğlu, Barış; Akalın, Ali Aykut; Özçelikkale, Altuğ (2021-07-02)
Regulation of Cytoskeletal Dynamics during T Cell Activation by Substrate Stiffness Özçelikkale, Altuğ; Upadhyaya, Arpita (2018-03-07) T lymphocytes are an integral part of the adaptive immune response. The detection of infectious agents critically depends on the interaction of T cells with antigen presenting cells, which have varying mechanical stiffn...

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