Antoıne Marıon

E-mail

amarion@metu.edu.tr

Department

Department of Chemistry

ORCID

0000-0002-8266-8957

Scopus Author ID

56288351300

Web of Science Researcher ID

AAC-4712-2019

Tetraphenyl-1,4-dioxin and Tetraphenyl-pyrane-4-one: Old Molecules, New Insights Soydan, Medine; Okyar, Burcu; ZORLU, YUNUS; Marıon, Antoıne; Özçubukçu, Salih (2023-05-01) Aggregation-induced emission (AIE) is a phenomenon wherecertainmolecules or materials become highly luminescent when they aggregateor come together in a condensed state, such as a solid or a solution.Moreover, new molecule...
The Q41R mutation in the HCV-protease enhances the reactivity towards MAVS by suppressing non-reactive pathways Zheng, Chen; Schneider, Markus; Marıon, Antoıne; Antes, Iris (2022-01-01) Recent experimental findings pointed out a new mutation in the HCV protease, Q41R, responsible for a significant enhancement of the enzyme's reactivity towards the mitochondrial antiviral-signaling protein (MAVS). The Q41R...
Activity-Based Photosensitizers with Optimized Triplet State Characteristics Toward Cancer Cell Selective and Image Guided Photodynamic Therapy Kilic, Eda; ELMAZOĞLU, ZÜBEYİR; Almammadov, Toghrul; KEPİL, DİLAY; Etienne, Thibaud; Marıon, Antoıne; Günbaş, Emrullah Görkem; Kolemen, Safacan (2022-01-01) © 2022 The Authors. Published by American Chemical Society.Activity-based theranostic photosensitizers are highly attractive in photodynamic therapy as they offer enhanced therapeutic outcome on cancer cells with an imagin...
Peptide stapling by late-stage Suzuki-Miyaura cross-coupling Gruss, Hendrik; Feiner, Rebecca C.; Mseya, Ridhiwan; Schroeder, David C.; Jewginski, Michat; Mueller, Kristian M.; Latajka, Rafat; Marıon, Antoıne; Sewald, Norbert (2022-01-01) The development of peptide stapling techniques to stabilise alpha-helical secondary structure motifs of peptides led to the design of modulators of protein-protein interactions, which had been considered undruggable for a ...
Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity. Gülseren, Gülcihan; Saylam, Aytül; Marıon, Antoıne; Özçubukçu, Salih (2021-09-29) The design of catalysts with greater control over catalytic activity and stability is a major challenge with substantial impact on fundamental chemistry and industrial applications. Due to their unparalleled diversity, sel...
Peptidotriazolamers Inhibit A beta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model Tonali, Nicolo; Hericks, Loreen; Schroeder, David C.; Kracker, Oliver; Krzemieniecki, Radoslaw; Kaffy, Julia; Le Joncour, Vadim; Laakkonen, Pirjo; Marıon, Antoıne; Ongeri, Sandrine; Dodero, Veronica I.; Sewald, Norbert (2021-05-01) In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in molecular weight between small-molecule drugs and protein-based drugs. Amyloid beta (A b...
Tuning the Biological Activity of RGD Peptides with Halotryptophanst Kemker, Isabell; Schroeder, David C.; Feiner, Rebecca C.; Mueller, Kristian M.; Marıon, Antoıne; Sewald, Norbert (2021-01-01) An array of L- and D-halotryptophans with different substituents at the indole moiety was synthesized employing either enzymatic halogenation by halogenases or incorporation of haloindoles using tryptophan synthase. Introd...
Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors Dultz, Georg; Shimakami, Tetsuro; Schneider, Markus; Murai, Kazuhisa; Yamane, Daisuke; Marıon, Antoıne; Zeitler, Tobias M.; Stross, Claudia; Grimm, Christian; Richter, Rebecca M.; Baeumer, Katrin; Yi, MinKyung; Biondi, Ricardo M.; Zeuzem, Stefan; Tampe, Robert; Antes, Iris; Lange, Christian M.; Welsch, Christoph (2020-10-01) Inhibitors against the NS3-4A protease of hepatitis C virus (HCV) have proven to be useful drugs in the treatment of HCV infection. Although variants have been identified with mutations that confer resistance to these inhi...
Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling Kemker, Isabell; Schnepel, Christian; Schroeder, David C.; Marıon, Antoıne; Sewald, Norbert (American Chemical Society (ACS), 2019-08-22) Halogenated L- or D-tryptophan obtained by biocatalytic halogenation was incorporated into RGD peptides together with a variety of alkyl or aryl boronic acids. Suzuki-Miyaura cross-coupling either in solution or on-resin r...
Actin stabilizing compounds show specific biological effects due to their binding mode Wang, Shuaijun; Crevenna, Alvaro H.; Ugur, Ilke; Marıon, Antoıne; Antes, Iris; Kazmaier, Uli; Hoyer, Maria; Lamb, Don C.; Gegenfurtner, Florian; Kliesmetes, Zane; Ziegenhain, Christoph; Enard, Wolfgang; Vollmar, Angelika; Zahler, Stefan (Springer Science and Business Media LLC, 2019-07-05) Actin binding compounds are widely used tools in cell biology. We compare the biological and biochemical effects of miuraenamide A and jasplakinolide, a structurally related prototypic actin stabilizer. Though both compoun...

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