Vasıf Nejat Hasırcı

E-mail

vhasirci@metu.edu.tr

Department

Department of Biology

Exosome-functionalized carbonate apatite nanoparticles as potential immunomodulatory mucosal vaccine adjuvant: physicochemical characterization and cytocompatibility on macrophages and buccal epithelial cells Sarasati, Andari; Wihadmadyatami, Hevi; Hasırcı, Vasıf Nejat; Ana, Ika Dewi (2026-02-01) Mucosal vaccines offer a promising strategy for inducing site-specific immunity, but their effectiveness depends heavily on safe and efficient delivery systems. This study aims to study exosome-functionalized carbonate apa...
In Vitro Assessment of Cellular Interaction and Trans-Buccal Permeability of Exosome-Functionalized Carbonate Apatite Nanoparticles as a Potential Mucosal Adjuvant Sarasati, Andari; Wihadmadyatami, Hevi; Hasırcı, Vasıf Nejat; Ana, Ika Dewi (2026-01-01) Background: Developing effective oral mucosal adjuvants remains a major challenge in mucosal vaccine design due to the epithelial barrier and limited local immune activation. This study aimed to develop and evaluate exosom...
Surface functionalized calcium phosphate bioceramics for immunomodulatory biomaterials Sarasati, Andari; Ana, Ika Dewi; YÜCEL, DENİZ; KENAR, HALİME; Wihadmadyatami, Hevi; Ozdemir, Neval Sevinc; Anggraeni, Rahmi; Hasırcı, Vasıf Nejat (2025-11-25) Calcium phosphate (CaP) bioceramics, including apatite (Ap)-based materials, are naturally biocompatible, but they frequently require surface functionalization to achieve optimal integration with biological systems, especi...
Establishment of an In Vitro Neurovascular Unit Model With Blood and Brain Components and Investigation of Its Blood–Brain Barrier Kole, Gozde E.; KOCAGÖZ, ZÜHTÜ TANIL; Hasırcı, Vasıf Nejat; YÜCEL, DENİZ (2025-11-01) The neurovascular unit (NVU), including the blood–brain barrier (BBB), governs the interaction between neural tissue and blood vessels. The BBB is a highly selective interface that regulates molecular exchange between the ...
Variations of chemical, physical, mechanical properties, and biological and antimicrobial effectiveness of Ti alloys by coating with CaP doped with different amounts of Zn via micro-arc oxidation (MAO) technique BÜYÜKSUNGUR, SENEM; Parau, Anca Constantina; Dinu, Mihaela; Pana, Iulian; Vitelaru, Catalin; Schmidt, Jürgen; Endoğan Tanır, Tuğba; Hasırcı, Vasıf Nejat; Vladescu (Dragomir), Alina; Hasırcı, Nesrin (2024-10-01) Titanium alloys are preferred metals as implant materials due to their advantageous combination of low density and high biocompatibility. However, the augmentation of implant surfaces with calcium-based coatings becomes es...
Nerve Tissue Model Development On A Micropatterned Surface Tamay, D. G.; Arslantunali-Sahin, D.; Isik, S.; Kole, G. E.; YÜCEL, DENİZ; Hasırcı, Nesrin; Hasırcı, Vasıf Nejat (2024-08-01)
MgCa-Based Alloys Modified with Zn- and Ga-Doped CaP Coatings Lead to Controlled Degradation and Enhanced Bone Formation in a Sheep Cranium Defect Model Gokyer, Seyda; Monsef, Yanad Abou; BÜYÜKSUNGUR, SENEM; Schmidt, Jurgen; Vladescu Dragomir, Alina; Uygur, Sencer; Uygur, Sencer; ORHAN, KAAN; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Yilgor, Pinar (2024-01-01) Mg-based biodegradable metallic implants are gaining increased attraction for applications in orthopedics and dentistry. However, their current applications are hampered by their high rate of corrosion, degradation, and ra...
Zn doped CaP coatings used for controlling the degradation rate of MgCa1 alloy: In vitro anticorrosive properties, sterilization and bacteria/cell-material interactions Schmidt, Jürgen; Pana, Iulian; Bystrova, Anna; Dinu, Mihaela; Dekhtyar, Yuri; Vitelaru, Catalin; Gorohovs, Marks; Marinescu, Ioana Maria; HURİ, PINAR; Tamay, Dilara Goksu; Juravlea, Gabriela Andreea; Buyuksungur, Senem; Parau, Anca Constantina; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Vladescu, Alina (2023-02-01) The purpose of this study was to investigate the effect of Zn doped CaP coatings prepared by micro-arc oxidation method, as a possible approach to control MgCa1 alloy degradation. All the prepared coatings comprised a calc...
In vitro cytotoxicity, corrosion and antibacterial efficiencies of Zn doped hydroxyapatite coated Ti based implant materials Buyuksungur, Senem; YILGÖR HURİ, PINAR; Schmidt, Jürgen; Pana, Iulian; Dinu, Mihaela; Vitelaru, Catalin; Kiss, Adrian E.; Tamay, Dilara Goksu; Hasırcı, Vasıf Nejat; Vladescu, Alina; Nesrin Hasirci, Hasirci (2023-01-01) Ti6Al4V alloy is successfully used as implant material in dental and orthopedic surgeries for years due to its much better compatibility, lower density, corrosion resistance, etc. compared to the other metals. Meantime, mo...
Advances in In Vitro Blood-Air Barrier Models and the Use of Nanoparticles in COVID-19 Research SEVİNÇ ÖZDEMİR, NEVAL; Belyaev, Dmitry; Castro, Manuel Nieto; Balakin, Sascha; Opitz, Joerg; Wihadmadyatami, Hevi; Anggraeni, Rahmi; YÜCEL, Deniz; KENAR, HALİME; Beshchasna, Natalia; Ana, Ika Dewi; Hasırcı, Vasıf Nejat (2023-01-01) Respiratory infections caused by coronaviruses (CoVs) have become a major public health concern in the past two decades as revealed by the emergence of SARS-CoV in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The most s...

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