Can Özen

E-mail

canozen@metu.edu.tr

Department

Graduate School of Natural and Applied Sciences

ORCID

0000-0002-3554-5778

Scopus Author ID

6507131483

Web of Science Researcher ID

ABA-9112-2020

DEVELOPMENT OF A MICROFLUIDIC PLATFORM TO MAINTAIN VIABILITY OF MICRO-DISSECTED TUMOR SLICES IN CULTURE Parsian, Maryam; MUTLU, PELİN; Yıldırım, Ender; Ildiz, Can; Özen, Can; GÜNDÜZ, UFUK (2022-05-26)
Development of a microfluidic platform to maintain viability of micro-dissected tumor slices in culture Parsian, Maryam; MUTLU, PELİN; Yıldırım, Ender; Ildiz, Can; Özen, Can; Gündüz, Ufuk (2022-05-01) © 2022 Author(s).One of the issues limiting the development of personalized medicine is the absence of realistic models that reflect the nature and complexity of tumor tissues. We described a new tissue culture approach th...
Increased Water Abstraction and Climate Change Have Substantial Effect on Morphometry, Salinity, and Biotic Communities in Lakes: Examples from the Semi-Arid Burdur Basin (Turkey) Colak, Mehmet Arda; Oztas, Baris; Özgencil, İbrahim Kaan; Soyluer, Melisa; Korkmaz, Mustafa; Ramirez-Garcia, Arely; Metin, Melisa; Yilmaz, Gultekin; Ertugrul, Serhat; TAVŞANOĞLU, ÜLKÜ NİHAN; Amorim, Cihelio Alves; Özen, Can; Apaydin Yagci, Meral; Yagci, Abdulkadir; Pacheco, Juan Pablo; Özkan, Korhan; Beklioğlu, Meryem; Jeppesen, Erik; Akyürek, Sevda Zuhal (2022-04-01) Global warming and altered precipitation patterns are predicted to intensify the water loss in semi-arid and arid regions, and such regions in Turkey will be particularly affected. Moreover, water abstraction, not least fo...
A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering Alissa Alam, Hani; Dalgıç, Ali Deniz; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2020-04-01) Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in t...
A new therapeutic combination for osteosarcoma: Gemcitabine and Clofazimine co-loaded liposomal formulation Caliskan, Yagmur; Dalgıç, Ali Deniz; Gerekci, Selin; Gulec, Ezgi A.; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2019-02-25) Osteosarcoma is the most common cancer in bone. Drug resistance is a challenge of current treatments that needs to be improved with novel treatment strategies. In this research, a new dual drug delivery system was develope...
Structure-based design, synthesis and anticancer effect of cyclic Smac-polyarginine peptides Khalily, Melek Parlak; GEREKÇİ, Selin; Gulec, Ezgi A.; Özen, Can; Özçubukçu, Salih (2018-11-01) The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the i...
Coaxial electrospun scaffolds for dual delivery of bioagents for bone tissue engineering. Keskin, Dilek; Tezcaner, Ayşen; Özen, Can (2018-09-13)
In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma BİBER, Aysenur; DURUSU, Ipek Z.; Özen, Can (2018-01-01) Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple myeloma (MM) treatment. In this work, we aimed to investigate the anticancer effect and mechanis...
Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom Doğan, Tuğba; BİBER, Aysenur; GEREKCİ, Selin; Hüsnügil, Hepşen Hazal; Özen, Can (2018-01-01) Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venom was determined for the first time. The electrophoretic profile of the crude venom showed a pr...
SmacN7-Oktaarjinin Peptit Konjugatlarinin Yapisal Düzenlenmesi ve Bunun Hücresel Alinima Ve Sitotoksisiteye Etkileri Parlak, Melek; Gerekçi, Selin; Güleç, Ezgi; Özen, Can; Özçubukçu, Salih (2017-09-14)

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