Can Özen

E-mail

canozen@metu.edu.tr

Department

Graduate School of Natural and Applied Sciences

ORCID

0000-0002-3554-5778

Scopus Author ID

6507131483

Web of Science Researcher ID

ABA-9112-2020

A predictive metabolomic model for FLT3 and NPM1 mutations in Acute Myeloid Leukemia patients Gerekci̇ Yeşi̇lyurt, Selin; Koyun, Derya; TOPRAK, SELAMİ KOÇAK; ÖZCAN, MUHİT; Özen, Can (2025-08-01) Cytogenetic abnormalities and gene mutations are essential for planning AML treatment. However, in Turkey, test results typically take 14–30 days. This delay emphasizes a critical need for rapid methods to deliver clinical...
The effects of salinization and climate change on shallow lakes of arid landscapes: two mesocosm experiments in two different climate zones in Türkiye Özkan, Korhan; Alves Amorim, Cihelio; Yılmaz, Gültekin; KORKMAZ, MUSTAFA; Pacheco, Juan Pablo; Yavuz, Gül Canan; Acar, Vildan; Can, Yasemin; Koru, Meltem; Özen, Can; AKYÜREK, SEVDA ZUHAL; BEKLİOĞLU, MERYEM; Jeppesen, Erik (2023-12-12)
Mesocosm Design and Implementation of Two Synchronized Case Study Experiments to Determine the Impacts of Salinization and Climate Change on the Structure and Functioning of Shallow Lakes Özkan, Korhan; et. al. (2023-07-01) Salinization of freshwater ecosystems is one of the major challenges imposed largely by climate change and excessive water abstraction for irrigated crop farming. Understanding how aquatic ecosystems respond to salinizatio...
DEVELOPMENT OF A MICROFLUIDIC PLATFORM TO MAINTAIN VIABILITY OF MICRO-DISSECTED TUMOR SLICES IN CULTURE Parsian, Maryam; MUTLU, PELİN; Yıldırım, Ender; Ildiz, Can; Özen, Can; GÜNDÜZ, UFUK (2022-05-26)
Development of a microfluidic platform to maintain viability of micro-dissected tumor slices in culture Parsian, Maryam; MUTLU, PELİN; Yıldırım, Ender; Ildiz, Can; Özen, Can; Gündüz, Ufuk (2022-05-01) © 2022 Author(s).One of the issues limiting the development of personalized medicine is the absence of realistic models that reflect the nature and complexity of tumor tissues. We described a new tissue culture approach th...
Increased Water Abstraction and Climate Change Have Substantial Effect on Morphometry, Salinity, and Biotic Communities in Lakes: Examples from the Semi-Arid Burdur Basin (Turkey) Colak, Mehmet Arda; Oztas, Baris; Özgencil, İbrahim Kaan; Soyluer, Melisa; Korkmaz, Mustafa; Ramirez-Garcia, Arely; Metin, Melisa; Yilmaz, Gultekin; Ertugrul, Serhat; TAVŞANOĞLU, ÜLKÜ NİHAN; Amorim, Cihelio Alves; Özen, Can; Apaydin Yagci, Meral; Yagci, Abdulkadir; Pacheco, Juan Pablo; Özkan, Korhan; Beklioğlu, Meryem; Jeppesen, Erik; Akyürek, Sevda Zuhal (2022-04-01) Global warming and altered precipitation patterns are predicted to intensify the water loss in semi-arid and arid regions, and such regions in Turkey will be particularly affected. Moreover, water abstraction, not least fo...
A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering Alissa Alam, Hani; Dalgıç, Ali Deniz; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2020-04-01) Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in t...
A new therapeutic combination for osteosarcoma: Gemcitabine and Clofazimine co-loaded liposomal formulation Caliskan, Yagmur; Dalgıç, Ali Deniz; Gerekci, Selin; Gulec, Ezgi A.; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2019-02-25) Osteosarcoma is the most common cancer in bone. Drug resistance is a challenge of current treatments that needs to be improved with novel treatment strategies. In this research, a new dual drug delivery system was develope...
Structure-based design, synthesis and anticancer effect of cyclic Smac-polyarginine peptides Khalily, Melek Parlak; GEREKÇİ, Selin; Gulec, Ezgi A.; Özen, Can; Özçubukçu, Salih (2018-11-01) The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the i...
Coaxial electrospun scaffolds for dual delivery of bioagents for bone tissue engineering. Keskin, Dilek; Tezcaner, Ayşen; Özen, Can (2018-09-13)

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