Can Özen

E-mail
canozen@metu.edu.tr
Department
Graduate School of Natural and Applied Sciences
Scopus Author ID
Web of Science Researcher ID
A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering
Alissa Alam, Hani; Dalgıç, Ali Deniz; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2020-04-01)
Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in t...
A new therapeutic combination for osteosarcoma: Gemcitabine and Clofazimine co-loaded liposomal formulation
Caliskan, Yagmur; Dalgıç, Ali Deniz; Gerekci, Selin; Gulec, Ezgi A.; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2019-02-25)
Osteosarcoma is the most common cancer in bone. Drug resistance is a challenge of current treatments that needs to be improved with novel treatment strategies. In this research, a new dual drug delivery system was develope...
Structure-based design, synthesis and anticancer effect of cyclic Smac-polyarginine peptides
Khalily, Melek Parlak; GEREKÇİ, Selin; Gulec, Ezgi A.; Özen, Can; Özçubukçu, Salih (2018-11-01)
The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the i...
Coaxial electrospun scaffolds for dual delivery of bioagents for bone tissue engineering.
Keskin, Dilek; Alam, Hani; Tezcaner, Ayşen; Dalgıç, Ali Deniz; Özen, Can (2018-09-13)
In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma
BİBER, Aysenur; DURUSU, Ipek Z.; Özen, Can (2018-01-01)
Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple myeloma (MM) treatment. In this work, we aimed to investigate the anticancer effect and mechanis...
Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom
Doğan, Tuğba; Igci, Nasit; BİBER, Aysenur; GEREKCİ, Selin; Hüsnügil, Hepşen Hazal; Izbirak, Afife; Özen, Can (2018-01-01)
Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venom was determined for the first time. The electrophoretic profile of the crude venom showed a pr...
SmacN7-Oktaarjinin Peptit Konjugatlarinin Yapisal Düzenlenmesi ve Bunun Hücresel Alinima Ve Sitotoksisiteye Etkileri
Parlak, Melek; Gerekçi, Selin; Güleç, Ezgi; Özen, Can; Özçubukçu, Salih (2017-09-14)
Synergistic Effect of Gemcitabine and Clofazimine in Co-loaded Liposomal Formulation for Multidrug Treatment Approach of Osteosarcoma
Çalışkan, Yağmur; Güleç, Ezgi; Gerekçi, Selin; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2017-07-19)
ntroduction: Osteosarcoma is the most common cancer in bone with high occurrence in children. The development of resistance is a challenge of current treatment strategies that needs to be improved with novel treatment stra...
Cellular Uptake and Cytotoxicity of Engineered SmacN7-Octaarginine Peptide Conjugates
Parlak, Melek; Gerekçi, Selin; Güleç, Ezgi; Özen, Can; Özçubukçu, Salih (2017-06-22)
Development of Chlorotoxin Peptide-Based Matrix Metalloproteinase-2 Inhibitors
Kesici, Mehmet Seçkin; Gerekçi, Selin; Güleç, Ezgi; Özen, Can; Özçubukçu, Salih (2017-06-22)
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