Can Özen

Graduate School of Natural and Applied Sciences
A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering
Alissa Alam, Hani; Dalgıç, Ali Deniz; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2020-04-01)
Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in t...
A new therapeutic combination for osteosarcoma: Gemcitabine and Clofazimine co-loaded liposomal formulation
Caliskan, Yagmur; Dalgıç, Ali Deniz; Gerekci, Selin; Gulec, Ezgi A.; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek (2019-02-25)
Osteosarcoma is the most common cancer in bone. Drug resistance is a challenge of current treatments that needs to be improved with novel treatment strategies. In this research, a new dual drug delivery system was develope...
Structure-based design, synthesis and anticancer effect of cyclic Smac-polyarginine peptides
Khalily, Melek Parlak; GEREKÇİ, Selin; Gulec, Ezgi A.; Özen, Can; Özçubukçu, Salih (2018-11-01)
The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the i...
In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma
BİBER, Aysenur; DURUSU, Ipek Z.; Özen, Can (2018-01-01)
Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple myeloma (MM) treatment. In this work, we aimed to investigate the anticancer effect and mechanis...
Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom
Doğan, Tuğba; Igci, Nasit; BİBER, Aysenur; GEREKCİ, Selin; Hüsnügil, Hepşen Hazal; Izbirak, Afife; Özen, Can (2018-01-01)
Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venom was determined for the first time. The electrophoretic profile of the crude venom showed a pr...
Anti-cancer effect of clofazimine as a single agent and in combination with cisplatin on U266 multiple myeloma cell line
Durusu, Ipek Z.; Husnugil, Hazal H.; ATAŞ, Heval; BİBER, Aysenur; GEREKCİ, Selin; Gulec, Ezgi A.; Özen, Can (2017-04-01)
Multiple Myeloma (MM) is a malignant neoplasm of bone marrow plasma B cells with high morbidity. Clofazimine (CLF) is an FDA-approved leprostatic, anti-tuberculosis, and anti-inflammatory drug that was previously shown to ...
Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behcet's disease severity
Kahraman, Tamer; Gucluler, Gozde; ŞİMŞEK, Ismail; Yagci, Fuat Cem; Yildirim, Muzaffer; Özen, Can; DİNÇ, Ayhan; Gürsel, Mayda; Ikromzoda, Lolai; Sutlu, Tolga; Gay, Stephen; Gursel, Ihsan (2017-01-01)
Behcet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin deriv...
Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells
LIMASALE, Yanuar Dwi Putra; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek; Banerjee, Sreeparna (2015-02-20)
Cyclooxygenase-2 (COX-2) is highly expressed in many different cancers. Therefore, the inhibition of the COX-2 pathway by a selective COX-2 inhibitor, celecoxib (CLX), may be an alternative strategy for cancer prevention a...
Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity
ERDES, Efe; Doğan, Tuğba; Cosar, Ilhan; Danisman, Tarik; Kunt, Kadir Bogac; Şeker, Tamay; YUCEL, Meral; Özen, Can (2014-11-03)
Background: Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms am...
Molecular Characterization and Peptidomic Analysis of Protoiurus kraepelini (Scorpiones:Iuridae) Venom
Doğan, Tuğba; Gerekçi, Selin; Ergenç, Merve; İğci, Naşit; Özel Demiralp, Fatma Duygu; Kunt, Kadir Boğaç; Özen, Can (2014-09-10)
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