Deniz Cansen Kahraman

E-mail

cansen@metu.edu.tr

Department

Graduate School of Informatics

ORCID

0000-0002-3381-5463

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors Hawash, Mohammed; Jaradat, Nidal; Abualhasan, Murad; ŞÜKÜROĞLU, MURAT KADİR; Qaoud, Mohammed T.; Kahraman, Deniz Cansen; Daraghmeh, Heba; Maslamani, Leen; Sawafta, Mais; Ratrout, Ala; Issa, Linda (2023-12-01) Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly used class of medications worldwide for the last three decades. Objectives: This study aimed to design and synthesize a novel series of ...
Repurposing Drugs to Target Molecular Networks in Hepatocellular Carcinoma Cells & Stem Cells for Innovative Treatment Strategies Sinoplu, Esra; TUNÇBAĞ, NURCAN; Kahraman, Deniz Cansen; ATALAY, RENGÜL (2023-12-01)
Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies Hawash, Mohammed; Ergun, Sezen Guntekin; Kahraman, Deniz Cansen; OLĞAÇ, ABDURRAHMAN; Hamel, Ernest; Cetin-Atalay, Rengul; BAYTAŞ, SULTAN (2023-08-05) Structurally diverse indole-3-pyrazole-5-carboxamide analogues (10-29) were designed, synthesized, and evaluated for their antiproliferative activity against three cancer cell lines (Huh7, MCF-7, and HCT116) using the sulf...
A Multi-Omics and Machine Learning-Based Predictor of Drug Sensitivity in Cancer Ozcan, Umut Onur; Mohammadvand, Navid; Izmirli, Burakcan; Akar, Etkin; Kahraman, Deniz Cansen; Doğan, Tunca (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) One of the most critical requirements of personalized medicine is to have prior knowledge about a tumor’s response to different treatments. To this end, large-scale experimental projects have been carried out with the spec...
Experimental validation of drug responses predicted by deep learning-based bioactivity models in hepatocellular carcinoma cell lines Akar, Etkin; Ozcan, Umut Onur; Mohammadvand, Navid; Doğan, Tunca; Kahraman, Deniz Cansen (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. Although it has high mortality rate, there are currently few drugs available as treatment options. Therefore, there is an urgent need for intensive ...
Disease Centric Large Scale De Novo Design of Drug Candidate Molecules with Graph Generative Deep Adversarial Networks Ünlü, Atabey; Çevrim, Elif; Sarıgün, Ahmet; Ataş, Heval; Koyaş, Altay; Çelikbilek, Hayriye; Kahraman, Deniz Cansen; Olğaç, Abdurrahman; Rifaioğlu, Ahmet Süreyya; Doğan, Tunca (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Discovering novel drug candidate molecules is one of the most fundamental and critical steps in drug development. It is especially challenging to develop new drug-based treatments for complex diseases, such as various canc...
A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation Kahraman, Deniz Cansen; Guven, Ebru Bilget; Aytac, Peri S.; Aykut, Gamze; Tozkoparan, Birsen; Atalay, Rengul Cetin (2022-09-01) Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the inciden...
Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents Hawash, Mohammed; Kahraman, Deniz Cansen; OLĞAÇ, ABDURRAHMAN; Ergun, Sezen Guntekin; Hamel, Ernest; Cetin-Atalay, Rengul; BAYTAŞ, SULTAN (2022-04-01) Novel compounds containing polar and nonpolar substitutions on the prop-2-en-1-on linker of the trans-indol-3-ylacrylamide scaffold were designed by modeling within the colchicine site of tubulin and then synthesized to de...
Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells. Narci, Kubra; Kahraman, Deniz Cansen; Koyas, Altay; Ersahin, Tulin; Tuncbag, Nurcan; Atalay, Rengul Cetin (2022-03-24) Background: Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC de...
Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency Yilmaz, Naz Surucu; et. al. (2022-01-01) NF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caused by mutations in the IKBKG gene. Conventionally, patients are afflicted with life threatening recurrent microbial infect...

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