The PI3K/AKT/mTOR interactive pathway

Date

2015-01-01

Author

ERŞAHIN, Tulin
Tunçbağ, Nurcan
Atalay, Rengül

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The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signalling pathway is hyperactivated or altered in many cancer types and regulates a broad range of cellular processes including survival, proliferation, growth, metabolism, angiogenesis and metastasis. The PI3K/ AKT/mTOR pathway is regulated by a wide-range of upstream signalling proteins and it regulates many downstream effectors by collaborating with various compensatory signalling pathways, primarily with RAF/MEK/ERK pathway. Limited clinical success of the available targeted therapeutic agents and challenges mediated by tumour heterogeneity across different cancer types emphasize the importance of alterations in the PI3K/AKT/mTOR pathway in the design of effective personalized treatment strategies. Here we report a comprehensive PI3K/AKT/mTOR network that represents the intricate crosstalk between compensatory pathways, which can be utilized to study the AKT signalling mechanism in detail and improve the personalized combinatorial therapeutic strategies.

Subject Keywords

Nf-kappa-b, Protein-kinase-b, Akt-dependent phosphorylation, Pleckstrin homology domain, Promotes cell-survival, Oncogene addiction, Molecular-mechanisms, Signaling pathways, Negative feedback, Coupled receptors

URI

https://hdl.handle.net/11511/30634

Journal

MOLECULAR BIOSYSTEMS

DOI

https://doi.org/10.1039/c5mb00101c

Collections

Graduate School of Informatics, Article

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Citation Formats

T. ERŞAHIN, N. Tunçbağ, and R. Atalay, “The PI3K/AKT/mTOR interactive pathway,” MOLECULAR BIOSYSTEMS, pp. 1946–1954, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30634.