Nanopatterned collagen tubes for vascular tissue engineering

Date

2008-08-01

Author

Zorlutuna, P.
Hasırcı, Nesrin
Hasırcı, Vasıf Nejat

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Nanopatterned (330 nm wide channels) type I collagen films were prepared by solvent casting on poly(dimethyl siloxane) (PDMS) templates. These films were rolled into tubular constructs and crosslinked. Tubular constructs were incubated under cell culture conditions for 28 days and examined by stereomicroscopy and scanning electron microscopy (SEM) for the integrity of the structure. The nanopatterned films were also seeded with human vascular smooth muscle cells (VSMCs) and examined after immunostaining with fluorescence microscopy and SEM to assess the cell phenotype and alignment on the nanopatterns on the films. Copyright (C) 2008 John Wiley & Sons, Ltd.

Subject Keywords

Tissue engineering, Blood vessel, Vascular smooth muscle cells., Nanopatterning, Collagen

URI

https://hdl.handle.net/11511/30674

Collections

Graduate School of Natural and Applied Sciences, Article