Metadata Management and Semantics in Microarray Repositories

The number of microarray and other high-throughput experiments on primary repositories keeps increasing as do the size and complexity of the results in response to biomedical investigations. Initiatives have been started on standardization of content, object model, exchange format and ontology. However, there are backlogs and inability to exchange data between microarray repositories, which indicate that there is a great need for a standard format and data management.


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The rapid increase in the size of biological sequence data owing to the advancements in high-throughput sequencing techniques, and the increased complexity of hypothesis-driven exploration of this data requiring massive number of similarity queries call for new approaches for managing sequence databases and analysis of this information. The metric space representation for sequences is suitable for similarity search and provides several sophisticated metric-indexing techniques. In this work, we provide a tho...
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Linked data initiative has been quite successful in terms of publishing and interlinking data over ontological structures. The success is due to answering semantically rich queries over highly structured data. The utilization of linked data structures are widely used in various domains to solve the problem of producing domain specific knowledge which can be interpreted by automated agents without any human interference. Cyber security field is one of the domains that suffer from the excessiveness of the raw...
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Multiomics data generated through various experiments and uploaded to public repositories have the potential to help researchers in understanding differentially expressed genes in different tissues. One such example is the blood-brain barrier (BBB), for which drug development is a problem because most therapeutic molecules cannot cross the BBB. Among the cell types that form the BBB, endothelial cells are the most important and functional members of the BBB [1], which prevent the entry of most molecules fro...
Citation Formats
F. Kocabas, T. Can, and N. Baykal, “Metadata Management and Semantics in Microarray Repositories,” BALKAN JOURNAL OF MEDICAL GENETICS, pp. 49–63, 2011, Accessed: 00, 2020. [Online]. Available: