PLGA bone plates reinforced with crosslinked PPF

Hasırcı, Vasıf Nejat
Trantolo, DJ
Gresser, JD
Wise, DL
Margolis, HC
In this study a matrix of poly(propylene fumarate) (PPF) was crosslinked with N-vinylpyrrolidone (NVP), 2-hydroxyethylmethacrylate (HEMA), or a mixture of NVP and ethyleneglycol dimethacrylate (EGDMA) in the presence of poly(lactide-co-glycolide) (PLGA) to reinforce and preserve the form of PLGA bone plates. The degree of crosslinkage varied depending on the crosslinker as shown by the rapid and almost complete leaching of NVP upon incubation in phosphate buffered saline at 37degrees C in 900 h and retention of 92% of HEMA. With the reinforced bone plates extracted for 72 h at room temperature methylene chloride, the extracted PLGA from NVP/PPF, NVP-EGDMA/PPF, and HEMA/PPF were 75.42% (w/w), 59.52% (w/w), and 30.86% (w/w), respectively. The flexural modulus and compressive strength of the crosslinked PPF reinforced bone plates were higher than that of the unreinforced bone plate. Atomic force microscopy showed that NVP/PPF reinforced PLGA bone plates eroded substantially (a mean surface roughness of 19.319 nm) whereas NVP-EGDMA-PPF reinforced bone plate showed a distinct crystalline organization (and a higher roughness, 43.525 nm). In conclusion, we propose the consideration of NVP-EGDMA/PPF reinforced PLGA as a biodegradable orthopedic implant material that has a lower likelihood of warping or failing catastrophically than the currently available materials. (C) 2002 Kluwer Academic Publishers.rid


HF and DFT studies and vibrational spectra of 1,2-bis(2-pyridyl) ethylene and its zinc (II) halide complexes
Ozhamam, Z.; Yurdakul, Murat Hayrettin; Yurdakul, S. (2007-03-11)
Ab initio restricted Hartree-Fock and density function theory calculations using BLYP, B3LYP and B3PW91 functionals were carried out to study molecular structure and vibrational spectrum of 1,2-bis(2-pyridyl)ethylene (which is abbreviated as bpe). Comparison of calculated and experimental results indicates the density functional B3LYP and BLYP/6-311G* methods are more accurate in predicting fundamental vibrational frequencies than the scaled other approaches. On the basis of calculated results, assignment o...
Synthesis, structural characterization and chemistry of tribenzoheterotriquinane based molecular structures.
Kepil, Dilay; Günbaş, Emrullah Görkem; Department of Chemistry (2020)
The synthesis of heteroatom containing derivatives of triquinane structure by the Mascal group represents an important development in the field of fundamental organic chemistry. Some derivatives of hererotriquinane structures showed unusual reactivity and structure properties. For example, oxonium ions are known as fleeting intermediates in certain reaction mechanisms. However, oxatriquinane, the oxygen containing analogue of heterotriquinane family, shows extreme stability. It can be chromatographed and su...
Pyrolysis mass spectrometric analysis of copolymer of polyacrylonitrile and polythiophene
Oğuz, Gülcan; Hacaloğlu, Jale; Department of Polymer Science and Technology (2004)
In the first part of this work, the structural and thermal characteristics of polyacrylonitrile, polyacrylonitrile films treated under the electrolysis conditions in the absence of thiophene, polythiophene and the mechanical mixture and a conducting copolymer of polyacrylonitrile/polythiophene have been studied by pyrolysis mass spectrometry technique. The thermal degradation of polyacrylonitrile occurs in three steps; evolution of HCN, monomer, low molecular weight oligomers due to random chain cleavages a...
Peptide stapling by late-stage Suzuki-Miyaura cross-coupling
Gruss, Hendrik; Feiner, Rebecca C.; Mseya, Ridhiwan; Schroeder, David C.; Jewginski, Michat; Mueller, Kristian M.; Latajka, Rafat; Marıon, Antoıne; Sewald, Norbert (2022-01-01)
The development of peptide stapling techniques to stabilise alpha-helical secondary structure motifs of peptides led to the design of modulators of protein-protein interactions, which had been considered undruggable for a long time. We disclose a novel approach towards peptide stapling utilising macrocyclisation by late-stage Suzuki-Miyaura cross-coupling of bromotryptophan-containing peptides of the catenin-binding domain of axin. Optimisation of the linker length in order to find a compromise between both...
Immobilization of invertase on a conducting polymer of 1-(4-nitrophenyl)-2,5-di(2-thienyl)-1H-pyrrole
Tuncagil, Sevinc; Kiralp, Senem; Varls, Serhat; Toppare, Levent Kamil (Elsevier BV, 2008-03-01)
In this study, immobilization of invertase was achieved on a conducting polymer of 1-(4-nitrophenyl)-2,5-di(2-thienyl)-1H-pyrrole) (SNS (NO2)) via electrochemical polymerization. Kinetic parameters, maximum reaction rate (V-max) and substrate affinity (K-m), optimum temperature and pH, operational and storage stabilities of immobilized enzyme were determined.
Citation Formats
V. N. Hasırcı, D. Trantolo, J. Gresser, D. Wise, and H. Margolis, “PLGA bone plates reinforced with crosslinked PPF,” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, pp. 159–167, 2002, Accessed: 00, 2020. [Online]. Available: