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Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus
Date
2009-09-18
Author
Davidson, Patricia M.
Ozcelik, Hayriye
Hasırcı, Vasıf Nejat
Reiter, Guenter
Anselme, Karine
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.
Subject Keywords
Differentiation
,
Proliferation
,
Deformability
,
Fibroblasts
,
Alignment
,
Lines
URI
https://hdl.handle.net/11511/31260
Journal
ADVANCED MATERIALS
DOI
https://doi.org/10.1002/adma.200900582
Collections
Graduate School of Natural and Applied Sciences, Article