Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

Date

2009-09-18

Author

Davidson, Patricia M.
Ozcelik, Hayriye
Hasırcı, Vasıf Nejat
Reiter, Guenter
Anselme, Karine

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.

Subject Keywords

Differentiation, Proliferation, Deformability, Fibroblasts, Alignment, Lines

URI

https://hdl.handle.net/11511/31260

Collections

Graduate School of Natural and Applied Sciences, Article