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Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

Davidson, Patricia M.
Ozcelik, Hayriye
Hasırcı, Vasıf Nejat
Reiter, Guenter
Anselme, Karine
Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.