Metin Zora

E-mail

zora@metu.edu.tr

Department

Department of Chemistry

ORCID

0000-0001-7764-2288

Scopus Author ID

6603747040

Web of Science Researcher ID

ABB-7678-2020

Synthesis of Selenium-Substituted Pyridine Derivatives Korkmaz, Esra; Zora, Metin (2023-03-13)
N-Propargylic β-enaminones in breast cancer cells: Cytotoxicity, apoptosis, and cell cycle analyses Ilhan, Suleyman; Atmaca, Harika; Yılmaz, Elif Serel; YILDIZ, ESRA; Zora, Metin (2023-01-01) Breast cancer is one of the most common cancers worldwide and the discovery of new cytotoxic agents is needed. Enaminones are regarded to be a significant structural motif that is found in a variety of pharmacologically ac...
Bioevaluation of Spiro N-Propargylic β-Enaminones as Anti-Breast Cancer Agents: In Vitro and Molecular Docking Studies Atmaca, Harika; Ilhan, Suleyman; Dündar, Buse Ayşen; Zora, Metin (2023-01-01) The study aimed to investigate the in vitro inhibitory activities of spiro N-propargylic β-enaminones, SPEs 1-31, against BCa cells, to perform in silico molecular docking studies to understand the nature of the interactio...
Endoplasmic Reticulum Stress-Induced Apoptotic Effects of Novel 1-Pyrroline (3,4-Dihydro-2H-pyrrole) Derivatives on Breast Cancer Cells Atmaca, Harika; Ilhan, Suleyman; YILDIZ, ESRA; Zora, Metin (2022-07-01) © 2022 Wiley-VHCA AG, Zurich, Switzerland.Heterocyclic compounds have emerged as promising and appealing scaffolds for developing effective antitumor agents. Here, the effects of synthesized 24 different 1-pyrroline deriva...
A facile synthesis of a novel family of heterotricyclic hybrids: Spiro-pyrrolopyridazines Dündar, Buse Ayşen; Zora, Metin (2022-01-01) An efficient strategy for the synthesis of spiro-pyrrolopyridazines has been developed. When reacted with hydrazine monohydrate, spiro-2H-pyrroles with a 1,4-diketone functionality produced a novel family of heterotricycli...
One-Pot Synthesis of 2-Acetyl-1 H-pyrroles from N-Propargylic β-Enaminones via Intermediacy of 1,4-Oxazepines Kanova, Nilay; Dündar, Buse Ayşen; Kelgokmen, Yilmaz; Zora, Metin (2021-01-01) A one-pot two-step protocol for the synthesis of 2-acetyl-1H-pyrroles from N-propargylic β-enaminones was described. When treated with zinc chloride in refluxing chloroform, N-propargylic β-enaminones produced in situ 2-me...
4-Propargyl-substituted 1H-pyrroles induce apoptosis and autophagy via extracellular signal-regulated signaling pathway in breast cancer Atmaca, Harika; Ilhan, Suleyman; Yılmaz, Elif Serel; Zora, Metin (2021-01-01) Novel pyrrole derivatives (PDs) with propargyl units (1–7) were investigated for their anticancer activity on breast cancer cells. The MTT assay was used to assess the cell viability. Morphological changes in human breast ...
A facile one-pot synthesis of 2-(prop-2-yn-1-ylidene)-2,3-dihydro-1,4-thiazepines Yılmaz, Elif Serel; Zora, Metin (Informa UK Limited, 2020-11-01) An unprecedented method for the synthesis of 2-(prop-2-yn-1-ylidene)-2,3-dihydro-1,4-thiazepines from N-(2,4-pentadiynyl) beta-enaminones is reported. Upon treatment with Lawesson's reagent, N-(2,4-pentadiynyl) beta-enamin...
A new approach for the synthesis of spiro and gem-dimethyl-substituted 1,4-oxazepines from N-propargylic beta-enaminones Karadeniz, Eda; Kelgökmen, Yılmaz; Zora, Metin (Wiley, 2020-11-01) An efficient and general method for the synthesis of spiro-1,4-oxazepines and 3,3-dimethyl-1,4-oxazepines is reported. When treated with ZnI2 and AgSbF6 in refluxing DCE, cyclohexane-embedded N-propargylic beta-enaminones ...
A facile synthesis of 6-chloro-2-methylene-2,3-dihydro-1,4-oxazepines from N-propargylic beta-enaminones Ibis, Ozge; Zora, Metin (Elsevier BV, 2020-11-01) A new and efficient method for the synthesis of 6-chloro-substituted 2-methylene-2,3-dihydro-1,4-oxazepines has been demonstrated. Upon treatment with N-chlorosuccinimide in acetonitrile, N-propargylic beta-enaminones unde...

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