Metin Zora

E-mail

zora@metu.edu.tr

Department

Department of Chemistry

ORCID

0000-0001-7764-2288

Scopus Author ID

6603747040

Web of Science Researcher ID

ABB-7678-2020

Rapid Access to 1,2,3,4-Tetrasubstituted Benzenes and 3-Alkenyl-1,2-dihydropyridines DÜNDAR ÖZDOĞAN, BUSE AYŞEN; Zora, Metin (2026-05-04) Herein, we report unprecedented protocols for the synthesis of 1,2,3,4-tetrasubstituted benzenes and 3-alkenyl-1,2-dihydropyridines from readily available N-methyl-N-propargyl beta-enaminones. When subjected to the reactio...
Facile one-pot synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines Korkmaz, Esra; Zora, Metin (2026-01-01) A straightforward and efficient one-pot protocol for the synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines is reported. When subjected to reaction with ethylenediamine in refluxing dioxane, bis-α,β-alk...
Synthesis of 1,3-Bis(4-phenyl-3H-benzo[b][1,4]diazepin-2-yl)propane Derivatives Korkmaz, Esra; Zora, Metin (2025-09-10)
A novel approach for the synthesis of tetrasubstituted benzene and 1,2-dihydropyridine derivatives Dündar, Buse Ayşen; Zora, Metin (2025-09-10)
Facile synthesis of unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-homopropargylic β-enaminones Yılmaz, Elif Serel; Kaya, Kerem; Zora, Metin (2025-01-01) In this paper, we have uncovered a new reaction of N-homopropargylic β-enaminones, i.e. N-(4-phenyl-3-butynyl)-β-enaminones. When subjected to a reaction with excess molecular iodine or N-iodosuccinimide in the presence of...
Novel Enyne-Modified 1,4-Thiazepines as Epidermal Growth Factor Receptor Inhibitors: Anticancer and Computational Studies Atmaca, Harika; Pulat, Cisil Camli; Ilhan, Suleyman; Yılmaz, Elif Serel; Zora, Metin (2024-12-26) 1,4-Thiazepines (TZEPs) featuring enyne modifications represent promising candidates in cancer therapy. We synthesized novel TZEP derivatives and assessed their cytotoxicity, apoptosis induction, EGFR inhibition, and molec...
InCl3-Catalyzed One-Pot Synthesis of Pyrrolo/Indolo- and Benzooxazepino-Fused Quinoxalines Aksakal, Nuray Esra; Zora, Metin (2024-07-01) In this paper, we describe an efficient InCl3-catalyzed two-component reaction of 1-(2-aminophenyl)pyrroles/indoles and 2-propargyloxybenzaldehydes for the direct synthesis of 12bH-benzo[6,7]1,4-oxazepino[4,5-a]pyrrolo/ind...
Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis Atmaca, Harika; Ilhan, Suleyman; Çamli Pulat, Çisil; Dündar, Buse Ayşen; Zora, Metin (2024-06-04) Cancer, characterized by uncontrolled cell proliferation, remains a global health challenge. Despite advancements in cancer treatment, drug resistance and adverse effects on normal cells remain challenging. The epidermal g...
Synthesis of 1,2-Dihydropyridine and Benzannulation Products Dündar, Buse Ayşen; Zora, Metin (2024-03-04)
Synthesis of 1,3-Bis-Pyrazole Derivatives Korkmaz, Esra; Zora, Metin (2024-03-04) Synthesis of 1,3-Bis-Pyrazole DerivativesEsra Korkmaz, Metin ZoraMiddle East Technical University, Department of Chemistry, 06800 Ankara, TürkiyeEmail: ekorkmaz@metu.edu.trPyrazoles are a significant class of nitrogen-c...

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