Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity

Doğan, Tuğba
Cosar, Ilhan
Danisman, Tarik
Kunt, Kadir Bogac
Şeker, Tamay
YUCEL, Meral
Özen, Can
Background: Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms among Turkish scorpions that provokes severe symptoms in envenomated victims.


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Peptides are increasingly present in all branches of medicine as innovative drugs, imaging agents, theragnostic, and constituent moieties of other sophisticated drugs such as peptide-drug conjugates. Due to new developments in chemical synthesis strategies, computational biology, recombinant technology, and chemical biology, peptide drug development has made a great progress in the last decade. Numerous natural peptides and peptide mimics have been obtained and studied, covering multiple therapeutic areas. ...
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Synthetic immunostimulatory nucleic acids such as CpG DNA are being harnessed therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify nucleic acid-based agents capable of more specifically modulating the immune system are being developed. The current study identifies a novel class of single-stranded oligoribonucleotides (ORN) containing unmethylated CpG motifs and a poly(G) run at the 3 end (CpG ORN) that directly stimulate human CD14 CD11c monocytes but not dendritic ...
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The increasing appeal of safe, cheap and effective treatments against various type of diseases has paved the way for the discovery and development of innovative peptide-based drug and drug delivery systems. The relative ease with which peptide based-materials can be synthesized and the wide range of synthetic techniques available have ensured that these materials can be tuned to adopt specific conformation or modified to contain specific functional groups. Our major focus in this thesis is developing peptid...
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Sedlacik, T.; Acar, O. K.; Studenovska, H.; Kotelnikov, I.; Kucka, J.; Konecna, Z.; Zikmund, T.; Kaiser, J.; KÖSE, GAMZE; Rypacek, F. (Royal Society of Chemistry (RSC), 2018-01-14)
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Peptidomic characterization and bioactivity screening of Leiurus abdullahbayrami (scorpiones: buthidae) venom /
Erdeş, Efe; Özen, Can; Gürsel, Mayda; Department of Biotechnology (2015)
Animal venoms consist of variety of bioactive molecules, small phenolic compounds to high molecular weight polypeptides, and they exhibit almost limitless biological functions. Scorpion venoms are complex cocktails of toxins from diverse structural origin; they are particularly enriched in bioactive peptides. These peptides gained excellent affinity for their targets through millions of years of evolutionary process. Therefore, scorpion venoms may be defined as naturally selected peptide libraries and this ...
Citation Formats
E. ERDES et al., “Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity,” JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, pp. 0–0, 2014, Accessed: 00, 2020. [Online]. Available: